2xbw: Difference between revisions

Revision as of 19:55, 26 July 2012

2xbw is a 2 chain structure of Factor Xa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Anselm L, Banner DW, Benz J, Zbinden KG, Himber J, Hilpert H, Huber W, Kuhn B, Mary JL, Otteneder MB, Panday N, Ricklin F, Stahl M, Thomi S, Haap W. Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5313-9. Epub 2010 Jul 1. PMID:20650636 doi:10.1016/j.bmcl.2010.06.126

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 [[Image:2xbw.png|left|200px]]
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 ===Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor===
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 ==See Also==
-*[[Factor Xa]]
+*[[Factor Xa|Factor Xa]]
 ==Reference==