1fza: Difference between revisions

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==Overview==

In blood coagulation, units of the protein fibrinogen pack together to, form a fibrin clot, but a crystal structure for fibrinogen is needed to, understand how this is achieved. The structure of a core fragment, (fragment D) from human fibrinogen has now been determined to 2.9 A, resolution. The 86K three-chained structure consists of a coiled-coil, region and two homologous globular entitles oriented at approximately 130, degrees to each other. Additionally, the covalently bound dimer of, fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by, molecular replacement with the model of fragment D.

In blood coagulation, units of the protein fibrinogen pack together to form a fibrin clot, but a crystal structure for fibrinogen is needed to understand how this is achieved. The structure of a core fragment (fragment D) from human fibrinogen has now been determined to 2.9 A resolution. The 86K three-chained structure consists of a coiled-coil region and two homologous globular entitles oriented at approximately 130 degrees to each other. Additionally, the covalently bound dimer of fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by molecular replacement with the model of fragment D.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Doolittle, R.F.]]

[[Category: Doolittle, R F.]]

[[Category: Everse, S.J.]]

[[Category: Everse, S J.]]

[[Category: Spraggon, G.]]

[[Category: CA]]

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[[Category: platelet]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 15~~:03:25 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:44:17 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-In blood coagulation, units of the protein fibrinogen pack together to, form a fibrin clot, but a crystal structure for fibrinogen is needed to, understand how this is achieved. The structure of a core fragment, (fragment D) from human fibrinogen has now been determined to 2.9 A, resolution. The 86K three-chained structure consists of a coiled-coil, region and two homologous globular entitles oriented at approximately 130, degrees to each other. Additionally, the covalently bound dimer of, fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by, molecular replacement with the model of fragment D.
+In blood coagulation, units of the protein fibrinogen pack together to form a fibrin clot, but a crystal structure for fibrinogen is needed to understand how this is achieved. The structure of a core fragment (fragment D) from human fibrinogen has now been determined to 2.9 A resolution. The 86K three-chained structure consists of a coiled-coil region and two homologous globular entitles oriented at approximately 130 degrees to each other. Additionally, the covalently bound dimer of fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by molecular replacement with the model of fragment D.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Doolittle, R.F.]]
+[[Category: Doolittle, R F.]]
-[[Category: Everse, S.J.]]
+[[Category: Everse, S J.]]
 [[Category: Spraggon, G.]]
 [[Category: CA]]
@@ Line 27: / Line 27: @@
 [[Category: platelet]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:03:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:44:17 2008''