3ud2: Difference between revisions

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[[Image:3ud2.png|left|200px]]
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{{STRUCTURE_3ud2|  PDB=3ud2  |  SCENE=  }}  
{{STRUCTURE_3ud2|  PDB=3ud2  |  SCENE=  }}  
===Crystal structure of Selenomethionine ZU5A-ZU5B protein domains of human erythrocyte ankyrin===
===Crystal structure of Selenomethionine ZU5A-ZU5B protein domains of human erythrocyte ankyrin===
{{ABSTRACT_PUBMED_22310050}}


==Disease==
[[http://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN]] Defects in ANK1 are a cause of spherocytosis type 1 (SPH1) [MIM:[http://omim.org/entry/182900 182900]]; also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive.<ref>PMID:8640229</ref><ref>PMID:11102985</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_22310050}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN]] Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.<ref>PMID:12456646</ref>  Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:12456646</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 22310050 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22310050}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:022310050</ref><references group="xtra"/>
<ref group="xtra">PMID:022310050</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ipsaro, J J.]]
[[Category: Ipsaro, J J.]]