Sandbox Reserved 430: Difference between revisions
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===Introduction=== | ===Introduction=== | ||
In this figure cisplatin is bound to a 12 base pair double stranded DNA, creating a 49° bend with an overall helix bend of 78°. This bend in the DNA is crucial to cisplatin’s role as an anticancer drug. | |||
Cisplatin, cis-PtCl2(NH3)2, is a chemotherapy drug, administered intravenously, used in the treatment of various types of cancer. This platinum-based drug acts in vivo by binding to two consecutive adjacent guanine bases in DNA. The binding of cisplatin bends the DNA, allowing for HMG-protein to bind. Once the HMG-protein is bound, de-stacking of the nucleotide base pairs occurs, which in turn kinks the DNA. With the HMG-protein bound to the DNA, the cell cannot properly repair the DNA, leading to apoptosis. | |||
<Structure load='1a84' size='500' frame='true' align='right' caption='Cisplatin bound to the DNA duplex dodecamer, in a 1,2-intrastrand crosslink, creating a 49° bend.' scene='Insert optional Scene name here' /> | <Structure load='1a84' size='500' frame='true' align='right' caption='Cisplatin bound to the DNA duplex dodecamer, in a 1,2-intrastrand crosslink, creating a 49° bend.' scene='Insert optional Scene name here' /> | ||
