Sandbox Reserved 427: Difference between revisions
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===Additional Features=== | ===Additional Features=== | ||
Insulin Receptor can become desensitized to the binding of insulin, and because of a lower affinity, insulin resistance develops. | |||
Insulin Resistance: Insulin resistance happens when the cells essentially don't open the door when insulin comes knocking. When this happens, the body puts out more insulin to stabilize blood glucose (and so the cells can use the glucose). A this allows for a vicious cycle where the cells become more and more desensitized as the concentration of insulin increases. This occurs when the insulin receptor cannot activate the Glu-4 once insulin binds, which lowers the storage of sugar. This resistance can be ameliorated by better dietary practice and increased intake of necessary vitamins and minerals. | |||
The insulin-binding cavity within the receptor homodimer (Fig. 1C) may provide a target for the design of helical mimetic nonpeptide agonists, perhaps achievable in part by molecules the size of antibiotics and could be “druggable.” | |||
Use of drugs with similar design to insulin as well as antibodies can provide a stronger affinity for the insulin receptor binding site, increasing sensitivity. | |||
===Credits=== | ===Credits=== | ||
