Sandbox Reserved 425: Difference between revisions
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===Introduction=== | ===Introduction=== | ||
- COMT responsible for degradation of catchol neurotransmitters including DA | - COMT responsible for degradation of catchol neurotransmitters including DA | ||
- PD symptoms result from low levels of DA | - PD symptoms result from low levels of DA | ||
- inhibiting COMT has potential to treat PD in conjunction with L-DOPA (a DA precursor currently used to treat PD) by increasing the bioavailability and stability of L-DOPA | - inhibiting COMT has potential to treat PD in conjunction with L-DOPA (a DA precursor currently used to treat PD) by increasing the bioavailability and stability of L-DOPA | ||
- 4PCM is a COMT inhibitor being studied to better understand inhibitor interactions with COMT in order to develop better inhibitors | - 4PCM is a COMT inhibitor being studied to better understand inhibitor interactions with COMT in order to develop better inhibitors | ||
- carbonyl oxygen interacts with Trp143 | - carbonyl oxygen interacts with Trp143 | ||
