Sandbox Reserved 425: Difference between revisions
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Met 40, Leu 198, Tyr 200, Trp 38, and Pro 174 pocket for 4-phenyl-7, 8-dihydroxycoumarine (4PCM) | Met 40, Leu 198, Tyr 200, Trp 38, and Pro 174 pocket for 4-phenyl-7, 8-dihydroxycoumarine (4PCM) | ||
<scene name='Sandbox_Reserved_425/Binding1/1'>Binding1</scene> | <scene name='Sandbox_Reserved_425/Binding1/1'>Binding1</scene> | ||
These are mostly hydrophobic interactions. Van der Waals interactions with these molecules, especially M40, and hydrogen bonds between W48 and K144 stabilize 4PCM. | |||
P174 restricts 4PCM mobility and limits interactions with the COMT protein. These stabilizing residues and evolutionarily conserved. | |||
===Additional Features=== | ===Additional Features=== | ||
