3np6: Difference between revisions

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[[Image:3np6.png|left|200px]]
==The crystal structure of Berberine bound to DNA d(CGTACG)==
<StructureSection load='3np6' size='340' side='right' caption='[[3np6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3np6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NP6 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nx5|3nx5]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3np6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3np6 RCSB], [http://www.ebi.ac.uk/pdbsum/3np6 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 A resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form.


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X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).,Ferraroni M, Bazzicalupi C, Bilia AR, Gratteri P Chem Commun (Camb). 2011 May 7;47(17):4917-9. Epub 2011 Mar 22. PMID:21431128<ref>PMID:21431128</ref>
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{{STRUCTURE_3np6|  PDB=3np6  |  SCENE=  }}


===The crystal structure of Berberine bound to DNA d(CGTACG)===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
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{{ABSTRACT_PUBMED_21431128}}
 
==About this Structure==
[[3np6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP6 OCA].
 
==Reference==
<ref group="xtra">PMID:021431128</ref><references group="xtra"/>
[[Category: Bazzicalupi, C.]]
[[Category: Bazzicalupi, C.]]
[[Category: Bilia, A R.]]
[[Category: Bilia, A R.]]
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