1c1e: Difference between revisions
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==Overview== | ==Overview== | ||
The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 | The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Wilson, I | [[Category: Wilson, I A.]] | ||
[[Category: Xu, J.]] | [[Category: Xu, J.]] | ||
[[Category: DMR]] | [[Category: DMR]] | ||
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[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:01:21 2008'' | ||
Revision as of 10:01, 21 February 2008
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CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN
Overview
The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.
About this Structure
1C1E is a Protein complex structure of sequences from Mus musculus with ENH and DMR as ligands. The following page contains interesting information on the relation of 1C1E with [Antibodies]. Full crystallographic information is available from OCA.
Reference
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:10600746
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