1cd8: Difference between revisions

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==Overview==

A secreted fragment of the extracellular portion of human CD8 alpha has, been expressed in CHO cells, and a deglycosylated and proteolyzed form of, this fragment has been crystallized. We report here the crystal structure, of this fragment as refined at 2.6 A resolution. The structure was solved, by molecular replacement using a superposition of ten variable domains, from immunoglobulin light chains as the search model. Only the N-terminal, 114 amino acids of CD8 alpha are visible in the electron density maps. The, domain formed by these residues possesses a fold typical of immunoglobulin, variable domains and associates to form Fv-like homodimers.

A secreted fragment of the extracellular portion of human CD8 alpha has been expressed in CHO cells, and a deglycosylated and proteolyzed form of this fragment has been crystallized. We report here the crystal structure of this fragment as refined at 2.6 A resolution. The structure was solved by molecular replacement using a superposition of ten variable domains from immunoglobulin light chains as the search model. Only the N-terminal 114 amino acids of CD8 alpha are visible in the electron density maps. The domain formed by these residues possesses a fold typical of immunoglobulin variable domains and associates to form Fv-like homodimers.

==Disease==

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[[Category: Single protein]]

[[Category: Axel, R.]]

[[Category: Hendrickson, W.A.]]

[[Category: Hendrickson, W A.]]

[[Category: Leahy, D.J.]]

[[Category: Leahy, D J.]]

[[Category: SO4]]

[[Category: surface glycoprotein]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:04:50 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-A secreted fragment of the extracellular portion of human CD8 alpha has, been expressed in CHO cells, and a deglycosylated and proteolyzed form of, this fragment has been crystallized. We report here the crystal structure, of this fragment as refined at 2.6 A resolution. The structure was solved, by molecular replacement using a superposition of ten variable domains, from immunoglobulin light chains as the search model. Only the N-terminal, 114 amino acids of CD8 alpha are visible in the electron density maps. The, domain formed by these residues possesses a fold typical of immunoglobulin, variable domains and associates to form Fv-like homodimers.
+A secreted fragment of the extracellular portion of human CD8 alpha has been expressed in CHO cells, and a deglycosylated and proteolyzed form of this fragment has been crystallized. We report here the crystal structure of this fragment as refined at 2.6 A resolution. The structure was solved by molecular replacement using a superposition of ten variable domains from immunoglobulin light chains as the search model. Only the N-terminal 114 amino acids of CD8 alpha are visible in the electron density maps. The domain formed by these residues possesses a fold typical of immunoglobulin variable domains and associates to form Fv-like homodimers.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Single protein]]
 [[Category: Axel, R.]]
-[[Category: Hendrickson, W.A.]]
+[[Category: Hendrickson, W A.]]
-[[Category: Leahy, D.J.]]
+[[Category: Leahy, D J.]]
 [[Category: SO4]]
 [[Category: surface glycoprotein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:35:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:04:50 2008''