Sandbox 31: Difference between revisions

Papain was first explored back in 1873 by G.C. Roy, who studied papaya juice.<ref name="worthington">http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref>  Later in 1879, the name papain was coined when the papain enzyme was first isolated by Wertz and Bouchut who noticed it had proteolytic properties.<ref name="worthington">http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref>  Papain was the second enzyme to have it's structure determined by x-ray crystallography.<ref name="drenth">http://www.ncbi.nlm.nih.gov/pubmed?term=Structure%20of%20papain%20refined%20at%201.65%20p%20resolution</ref>  In the 1980s the active site structure was modeled to a 1.65 Angstrom resolution. <ref name="structurepap">http://www.ncbi.nlm.nih.gov/pubmed?term=Structure%20of%20papain%20refined%20at%201.65%20p%20resolution</ref> Extensive research has be done on the structure and activity of papain and its potential medicinal use. This study continues today with study on stability of the papain enzyme and its use as a digestive enzyme supplement.<ref>http://www.webmd.com/vitamins-supplements/ingredientmono-69-PAPAIN.aspx?activeIngredientId=69&activeIngredientName=PAPAIN</ref>