Anthrax edema factor: Difference between revisions
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to a Jmol applet. Check out the other buttons as well! | to a Jmol applet. Check out the other buttons as well! | ||
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'''Anthrax edema factor''' (EF) is an enzyme which is part of the Bacillus anthracis anthrax toxin. The anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. It causes the cellular level of cAMP to increase thus upsetting water homeostasis and causing disruption of signaling pathways. | '''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. It causes the cellular level of cAMP to increase thus upsetting water homeostasis and causing disruption of signaling pathways. | ||
==3D structures of anthrax edema factor== | ==3D structures of anthrax edema factor== | ||
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[[1xfw]] - EF residues 33-800 + calmodulin + cAMP<br /> | [[1xfw]] - EF residues 33-800 + calmodulin + cAMP<br /> | ||
[[1xfx]], [[1xfy]], [[1xfz]] - EF residues 33-800 + calmodulin | [[1xfx]], [[1xfy]], [[1xfz]] - EF residues 33-800 + calmodulin | ||
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