3hpx: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "3hpx" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3hpx| PDB=3hpx | SCENE= }} | {{STRUCTURE_3hpx| PDB=3hpx | SCENE= }} | ||
===Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)=== | ===Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)=== | ||
{{ABSTRACT_PUBMED_22352945}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LEU1_MYCTU LEU1_MYCTU]] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity). | |||
-- | |||
==About this Structure== | ==About this Structure== | ||
[[3hpx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3hpx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPX OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022352945</ref><references group="xtra"/> | <ref group="xtra">PMID:022352945</ref><references group="xtra"/><references/> | ||
[[Category: 2-isopropylmalate synthase]] | [[Category: 2-isopropylmalate synthase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis h37rv]] | ||
[[Category: Baker, E N.]] | [[Category: Baker, E N.]] | ||
[[Category: Koon, N.]] | [[Category: Koon, N.]] | ||
Revision as of 07:34, 20 June 2013
Crystal structure of Mycobacterium tuberculosis LeuA active site domain 1-425 (truncation mutant delta:426-644)
Template:ABSTRACT PUBMED 22352945
Function
[LEU1_MYCTU] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).
About this Structure
3hpx is a 2 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
- Huisman FH, Koon N, Bulloch EM, Baker HM, Baker EN, Squire CJ, Parker EJ. Removal of the C-Terminal Regulatory Domain of alpha-Isopropylmalate Synthase Disrupts Functional Substrate Binding. Biochemistry. 2012 Mar 6. PMID:22352945 doi:10.1021/bi201717j
