Sandbox 49: Difference between revisions
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{{Template:Oberholser_Sandbox_Reservation}}<applet load='1hpl' size='300' frame='true' align='right' caption='<scene name='caption'/> | {{Template:Oberholser_Sandbox_Reservation}}<applet load='1hpl' size='300' frame='true' align='right' caption='<scene name='caption'/> | ||
=Introduction= | ==Introduction== | ||
Lipases represent a critical class of enzymes that functions in the breakdown of triacylglycerides. Produced by the pancreas, lipase catalyzes the hydrolysis of triacylglyercols at their 1 and 3 carbons, resulting the in the production of 2-monoacylglycerols and free fatty acids. Modeled here is horse pancreatic lipase. | Lipases represent a critical class of enzymes that functions in the breakdown of triacylglycerides. Produced by the pancreas, lipase catalyzes the hydrolysis of triacylglyercols at their 1 and 3 carbons, resulting the in the production of 2-monoacylglycerols and free fatty acids. Modeled here is horse pancreatic lipase. | ||
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==Ca Ligand== | ==Ca Ligand== | ||
Lipase also has a Ca Ligand that noncovalently binds to residues: Glu 187, Arg 190, Asp 192, Asp 195. There is one Calcium ion bound per chain in the enzyme, so that makes a total of 2 calcium ligands per enzyme. The Ca ligand is an important factor involved in the activation of the enzyme. | Lipase also has a Ca Ligand that noncovalently binds to residues: Glu 187, Arg 190, Asp 192, Asp 195. There is one Calcium ion bound per chain in the enzyme, so that makes a total of 2 calcium ligands per enzyme. The Ca ligand is an important factor involved in the activation of the enzyme. | ||
==Inhibition and Activation== | |||
==References== | ==References== | ||
