1erh: Difference between revisions
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==Overview== | ==Overview== | ||
The cell surface antigen CD59 is an inhibitor of complement-mediated lysis | The cell surface antigen CD59 is an inhibitor of complement-mediated lysis and a member of the Ly6 superfamily (Ly6SF) of cysteine-rich cell-surface molecules whose sequences are related to those of snake venom neurotoxins. The three-dimensional solution structure of a recombinant form of the extracellular region of the molecule (residues 1-70 of the mature protein; sCD59) has been solved by 2D NMR methods. sCD59 is a relatively flat, disk-shaped molecule consisting of a two-standed beta-sheet finger loosely packed against a protein core formed by a three-stranded beta-sheet and a short helix. Structure calculations allowed an unambiguous assignment of the disulfide-bonded cysteine pairs as 3-26, 6-13, 19-39, 45-63, and 64-69. The topology of sCD59 is similar to that of the snake venom neurotoxins and consistent with an evolutionary relationship existing between the Ly6SF and the neurotoxins. | ||
==Disease== | ==Disease== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Campbell, I | [[Category: Campbell, I D.]] | ||
[[Category: Davis, S | [[Category: Davis, S J.]] | ||
[[Category: Driscoll, P | [[Category: Driscoll, P C.]] | ||
[[Category: Kieffer, B.]] | [[Category: Kieffer, B.]] | ||
[[Category: Merwe, P | [[Category: Merwe, P A.Van Der.]] | ||
[[Category: Willis, A | [[Category: Willis, A C.]] | ||
[[Category: complement factor]] | [[Category: complement factor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:43 2008'' | ||
