1f3d: Difference between revisions

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==Overview==

The crystal structure of the complex of a catalytic antibody with its, cationic hapten at 1.9-A resolution demonstrates that the hapten amidinium, group is stabilized through an ionic pair interaction with the carboxylate, of a combining-site residue. The location of this carboxylate allows it to, act as a general base in an allylic rearrangement. When compared with, structures of other antibody complexes in which the positive moiety of the, hapten is stabilized mostly by cation-pi interactions, this structure, shows that the amidinium moiety is a useful candidate to elicit a, carboxylate in an antibody combining site at a predetermined location with, respect to the hapten. More generally, this structure highlights the, advantage of a bidentate hapten for the programmed positioning of a, chemically reactive residue in an antibody through charge complementarity, to the hapten.

The crystal structure of the complex of a catalytic antibody with its cationic hapten at 1.9-A resolution demonstrates that the hapten amidinium group is stabilized through an ionic pair interaction with the carboxylate of a combining-site residue. The location of this carboxylate allows it to act as a general base in an allylic rearrangement. When compared with structures of other antibody complexes in which the positive moiety of the hapten is stabilized mostly by cation-pi interactions, this structure shows that the amidinium moiety is a useful candidate to elicit a carboxylate in an antibody combining site at a predetermined location with respect to the hapten. More generally, this structure highlights the advantage of a bidentate hapten for the programmed positioning of a chemically reactive residue in an antibody through charge complementarity to the hapten.

==About this Structure==

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[[Category: haptenic charge]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of the complex of a catalytic antibody with its, cationic hapten at 1.9-A resolution demonstrates that the hapten amidinium, group is stabilized through an ionic pair interaction with the carboxylate, of a combining-site residue. The location of this carboxylate allows it to, act as a general base in an allylic rearrangement. When compared with, structures of other antibody complexes in which the positive moiety of the, hapten is stabilized mostly by cation-pi interactions, this structure, shows that the amidinium moiety is a useful candidate to elicit a, carboxylate in an antibody combining site at a predetermined location with, respect to the hapten. More generally, this structure highlights the, advantage of a bidentate hapten for the programmed positioning of a, chemically reactive residue in an antibody through charge complementarity, to the hapten.
+The crystal structure of the complex of a catalytic antibody with its cationic hapten at 1.9-A resolution demonstrates that the hapten amidinium group is stabilized through an ionic pair interaction with the carboxylate of a combining-site residue. The location of this carboxylate allows it to act as a general base in an allylic rearrangement. When compared with structures of other antibody complexes in which the positive moiety of the hapten is stabilized mostly by cation-pi interactions, this structure shows that the amidinium moiety is a useful candidate to elicit a carboxylate in an antibody combining site at a predetermined location with respect to the hapten. More generally, this structure highlights the advantage of a bidentate hapten for the programmed positioning of a chemically reactive residue in an antibody through charge complementarity to the hapten.
 ==About this Structure==
@@ Line 25: / Line 25: @@
 [[Category: haptenic charge]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:45:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:22 2008''