1r9k: Difference between revisions

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[[Image:1r9k.png|left|200px]]
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{{STRUCTURE_1r9k|  PDB=1r9k  |  SCENE=  }}  
{{STRUCTURE_1r9k|  PDB=1r9k  |  SCENE=  }}  
===Representative solution structure of the catalytic domain of SopE2===
===Representative solution structure of the catalytic domain of SopE2===
{{ABSTRACT_PUBMED_15379540}}


 
==Function==
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[[http://www.uniprot.org/uniprot/SOPE2_SALTY SOPE2_SALTY]] Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2.<ref>PMID:10931274</ref> <ref>PMID:15321998</ref> 
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{{ABSTRACT_PUBMED_15379540}}


==About this Structure==
==About this Structure==
[[1r9k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9K OCA].  
[[1r9k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9K OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:015379540</ref><references group="xtra"/>
<ref group="xtra">PMID:015379540</ref><references group="xtra"/><references/>
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
[[Category: Salty]]
[[Category: Bagby, S.]]
[[Category: Bagby, S.]]
[[Category: Galyov, E E.]]
[[Category: Galyov, E E.]]
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