3ztl: Difference between revisions

Line 1:

[[~~Image~~:3ztl.~~jpg|left|200px~~]]

==Crystal structure of decameric form of Peroxiredoxin I from Schistosoma mansoni==

== Structural highlights ==

<table><tr><td colspan='2'>[[3ztl]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTL FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ztl RCSB], [http://www.ebi.ac.uk/pdbsum/3ztl PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

2-Cys peroxiredoxins (Prxs) play two different roles depending on the physiological status of the cell. They are thioredoxin-dependent peroxidases under low oxidative stress and ATP-independent chaperones upon exposure to high peroxide concentrations. These alternative functions have been associated with changes in the oligomerization state from low-(LMW) to high-molecular-weight (HMW) species. Here we present the structures of Schistosoma mansoni PrxI in both states: the LMW decamer and the HMW 20-mer formed by two stacked decamers. The latter is the structure of a 2-Cys Prx chaperonic form. Comparison of the structures sheds light on the mechanism by which chemical stressors, such as high H(2)O(2) concentration and acidic pH, are sensed and translated into a functional switch in this protein family. We also propose a model to account for the in vivo formation of long filaments of stacked Prx rings.

<!--

Moonlighting by different stressors: crystal structure of the chaperone species of a 2-cys peroxiredoxin.,Saccoccia F, Di Micco P, Boumis G, Brunori M, Koutris I, Miele AE, Morea V, Sriratana P, Williams DL, Bellelli A, Angelucci F Structure. 2012 Mar 7;20(3):429-39. PMID:22405002<ref>PMID:22405002</ref>

~~The line below this paragraph~~, ~~containing "STRUCTURE_3ztl"~~, ~~creates the "~~Structure ~~Box" on the page~~.

~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display~~.

-->

~~{{STRUCTURE_3ztl| PDB=3ztl | SCENE= }}~~

~~===Crystal structure of decameric form~~ of ~~Peroxiredoxin I from Schistosoma mansoni===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

~~<!--~~

~~The line below this paragraph, {{ABSTRACT_PUBMED_22405002}}, adds the Publication Abstract to~~ the ~~page~~

__TOC__

~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22405002 is the PubMed ID number~~.

</StructureSection>

-->

~~{{ABSTRACT_PUBMED_22405002}}~~

~~==About this Structure==~~

~~[[3ztl]] is a 10 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTL OCA].~~

==~~Reference~~==

<~~ref group="xtra">PMID:022405002<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Peroxiredoxin]]

[[Category: Schistosoma mansoni]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:3ztl.jpg|left|200px]]
+==Crystal structure of decameric form of Peroxiredoxin I from Schistosoma mansoni==
+<StructureSection load='3ztl' size='340' side='right' caption='[[3ztl]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ztl]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTL FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ztl RCSB], [http://www.ebi.ac.uk/pdbsum/3ztl PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+-Cys peroxiredoxins (Prxs) play two different roles depending on the physiological status of the cell. They are thioredoxin-dependent peroxidases under low oxidative stress and ATP-independent chaperones upon exposure to high peroxide concentrations. These alternative functions have been associated with changes in the oligomerization state from low-(LMW) to high-molecular-weight (HMW) species. Here we present the structures of Schistosoma mansoni PrxI in both states: the LMW decamer and the HMW 20-mer formed by two stacked decamers. The latter is the structure of a 2-Cys Prx chaperonic form. Comparison of the structures sheds light on the mechanism by which chemical stressors, such as high H(2)O(2) concentration and acidic pH, are sensed and translated into a functional switch in this protein family. We also propose a model to account for the in vivo formation of long filaments of stacked Prx rings.
-<!--
+Moonlighting by different stressors: crystal structure of the chaperone species of a 2-cys peroxiredoxin.,Saccoccia F, Di Micco P, Boumis G, Brunori M, Koutris I, Miele AE, Morea V, Sriratana P, Williams DL, Bellelli A, Angelucci F Structure. 2012 Mar 7;20(3):429-39. PMID:22405002<ref>PMID:22405002</ref>
-The line below this paragraph, containing "STRUCTURE_3ztl", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_3ztl|  PDB=3ztl  |  SCENE=  }}
-===Crystal structure of decameric form of Peroxiredoxin I from Schistosoma mansoni===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_22405002}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 22405002 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_22405002}}
-==About this Structure==
-[[3ztl]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTL OCA].
-==Reference==
-<ref group="xtra">PMID:022405002</ref><references group="xtra"/>
 [[Category: Peroxiredoxin]]
 [[Category: Schistosoma mansoni]]