1fq9: Difference between revisions

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==Overview==

The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex, at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting, FGF-FGFR binding. Heparin also interacts with FGFR in the adjoining 1:1, FGF:FGFR complex to promote FGFR dimerization. The 6-O-sulfate group of, heparin plays a pivotal role in mediating both interactions. The, unexpected stoichiometry of heparin binding in the structure led us to, propose a revised model for FGFR dimerization. Biochemical data in support, of this model are also presented. This model provides a structural basis, for FGFR activation by small molecule heparin analogs and may facilitate, the design of heparin mimetics capable of modulating FGF signaling.

The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting FGF-FGFR binding. Heparin also interacts with FGFR in the adjoining 1:1 FGF:FGFR complex to promote FGFR dimerization. The 6-O-sulfate group of heparin plays a pivotal role in mediating both interactions. The unexpected stoichiometry of heparin binding in the structure led us to propose a revised model for FGFR dimerization. Biochemical data in support of this model are also presented. This model provides a structural basis for FGFR activation by small molecule heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling.

==Disease==

Line 16:

[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Eliseenkova, A.V.]]

[[Category: Eliseenkova, A V.]]

[[Category: Ibrahimi, O.A.]]

[[Category: Ibrahimi, O A.]]

[[Category: Linhardt, R.J.]]

[[Category: Linhardt, R J.]]

[[Category: Mohammadi, M.]]

[[Category: Plotnikov, A.N.]]

[[Category: Plotnikov, A N.]]

[[Category: Schlessinger, J.]]

[[Category: Yayon, A.]]

[[Category: Yeh, B.K.]]

[[Category: Yeh, B K.]]

[[Category: b-trefoil fold]]

[[Category: i-set subgroup within the immunoglobulin superfamily]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:41:28 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex, at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting, FGF-FGFR binding. Heparin also interacts with FGFR in the adjoining 1:1, FGF:FGFR complex to promote FGFR dimerization. The 6-O-sulfate group of, heparin plays a pivotal role in mediating both interactions. The, unexpected stoichiometry of heparin binding in the structure led us to, propose a revised model for FGFR dimerization. Biochemical data in support, of this model are also presented. This model provides a structural basis, for FGFR activation by small molecule heparin analogs and may facilitate, the design of heparin mimetics capable of modulating FGF signaling.
+The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting FGF-FGFR binding. Heparin also interacts with FGFR in the adjoining 1:1 FGF:FGFR complex to promote FGFR dimerization. The 6-O-sulfate group of heparin plays a pivotal role in mediating both interactions. The unexpected stoichiometry of heparin binding in the structure led us to propose a revised model for FGFR dimerization. Biochemical data in support of this model are also presented. This model provides a structural basis for FGFR activation by small molecule heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Eliseenkova, A.V.]]
+[[Category: Eliseenkova, A V.]]
-[[Category: Ibrahimi, O.A.]]
+[[Category: Ibrahimi, O A.]]
-[[Category: Linhardt, R.J.]]
+[[Category: Linhardt, R J.]]
 [[Category: Mohammadi, M.]]
-[[Category: Plotnikov, A.N.]]
+[[Category: Plotnikov, A N.]]
 [[Category: Schlessinger, J.]]
 [[Category: Yayon, A.]]
-[[Category: Yeh, B.K.]]
+[[Category: Yeh, B K.]]
 [[Category: b-trefoil fold]]
 [[Category: i-set subgroup within the immunoglobulin superfamily]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:48:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:41:28 2008''