4ago: Difference between revisions
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[[Image:4ago. | [[Image:4ago.png|left|200px]] | ||
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The line below this paragraph, {{ | The line below this paragraph, {{ABSTRACT_PUBMED_22439615}}, adds the Publication Abstract to the page | ||
(as it appears on PubMed at http://www.pubmed.gov), where | (as it appears on PubMed at http://www.pubmed.gov), where 22439615 is the PubMed ID number. | ||
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{{ | {{ABSTRACT_PUBMED_22439615}} | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017015838</ref><references group="xtra"/> | <ref group="xtra">PMID:022439615</ref><ref group="xtra">PMID:017015838</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boeckler, F M.]] | [[Category: Boeckler, F M.]] | ||
Revision as of 18:24, 2 May 2012
Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174
Template:ABSTRACT PUBMED 22439615
About this Structure
4ago is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wilcken R, Liu X, Zimmermann MO, Rutherford TJ, Fersht AR, Joerger AC, Boeckler FM. Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53. J Am Chem Soc. 2012 Apr 18;134(15):6810-8. Epub 2012 Apr 5. PMID:22439615 doi:10.1021/ja301056a
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
