Lipase: Difference between revisions

In this structure, only one of the two identical chains is shown for lipase and colipase to better visualize the interaction of substrates and ligands with the protein. <scene name='Lipase/Lipase_colipase_inhibitor/1'>Methoxyundecylphosphinic acid (MUP)</scene>, a C11 alkyl phosphonate, is a competitive inhibitor of pancreatic lipase which binds to the active site.  It is highlighted in purple.  There are also five B-octylglucoside molecules in association with lipase.  They are shown in grey and red.  MUP forms hydrogen bonds with <scene name='Lipase/Inhibitor_interaction/1'>four residues</scene>:  Ser 152 and His 263, which are part of the catalytic triad, and Phe 77 and Leu 153 which are the stabilizing residues located in the oxyanion hole <ref name= "1LPB PDB SUM">[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1lpb&template=main.html] 1LPB PDB SUM</ref>.