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[[Image:2lo0.png|left|200px]]
==Solution structure of the Get5 carboxyl domain from A. fumigatus==
<StructureSection load='2lo0' size='340' side='right' caption='[[2lo0]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2lo0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO0 OCA]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vej|3vej]], [[2lnz|2lnz]]</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AFUA_5G01770 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=746128 Aspergillus fumigatus])</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lo0 RCSB], [http://www.ebi.ac.uk/pdbsum/2lo0 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tail-anchored trans-membrane proteins are targeted to membranes post-translationally. The proteins Get4 and Get5 form an obligate complex that catalyzes the transfer of tail-anchored proteins destined to the endoplasmic reticulum from Sgt2 to the cytosolic targeting factor Get3. Get5 forms a homodimer mediated by its carboxyl domain. We show here that a conserved motif exists within the carboxyl domain. A high resolution crystal structure and solution NMR structures of this motif reveal a novel and stable helical dimerization domain. We additionally determined a solution NMR structure of a divergent fungal homolog, and comparison of these structures allows annotation of specific stabilizing interactions. Using solution x-ray scattering and the structures of all folded domains, we present a model of the full-length Get4/Get5 complex.


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Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex.,Chartron JW, Vandervelde DG, Rao M, Clemons WM Jr J Biol Chem. 2012 Mar 9;287(11):8310-7. Epub 2012 Jan 17. PMID:22262836<ref>PMID:22262836</ref>
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{{STRUCTURE_2lo0|  PDB=2lo0  |  SCENE=  }}


===Solution structure of the Get5 carboxyl domain from A. fumigatus===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
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{{ABSTRACT_PUBMED_22262836}}
 
==About this Structure==
[[2lo0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO0 OCA].
 
==Reference==
<ref group="xtra">PMID:022262836</ref><references group="xtra"/>
[[Category: Aspergillus fumigatus]]
[[Category: Aspergillus fumigatus]]
[[Category: Chartron, J W.]]
[[Category: Chartron, J W.]]
Retrieved from "https://proteopedia.org/2lo0"