1gtr: Difference between revisions

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==Overview==

The refined crystal structure of Escherichia coli glutaminyl transfer RNA, synthetase complexed with transfer RNA(Gln) and ATP reveals that the, structure of the anticodon loop of the enzyme-bound tRNA(Gln) differs, extensively from that of the known crystal structures of uncomplexed tRNA, molecules. The anticodon stem is extended by two non-Watson-Crick base, pairs, leaving the three anti-codon bases unpaired and splayed out to bind, snugly into three separate complementary pockets in the protein. These, interactions suggest that the entire anticodon loop provides essential, sites for glutaminyl tRNA synthetase discrimination among tRNA molecules.

The refined crystal structure of Escherichia coli glutaminyl transfer RNA synthetase complexed with transfer RNA(Gln) and ATP reveals that the structure of the anticodon loop of the enzyme-bound tRNA(Gln) differs extensively from that of the known crystal structures of uncomplexed tRNA molecules. The anticodon stem is extended by two non-Watson-Crick base pairs, leaving the three anti-codon bases unpaired and splayed out to bind snugly into three separate complementary pockets in the protein. These interactions suggest that the entire anticodon loop provides essential sites for glutaminyl tRNA synthetase discrimination among tRNA molecules.

==About this Structure==

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[[Category: Glutamine--tRNA ligase]]

[[Category: Single protein]]

[[Category: Perona, J.J.]]

[[Category: Perona, J J.]]

[[Category: Rould, M.A.]]

[[Category: Rould, M A.]]

[[Category: Steitz, T.A.]]

[[Category: Steitz, T A.]]

[[Category: ATP]]

[[Category: complex (ligase/trna)]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 15~~:54:48 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:53:53 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The refined crystal structure of Escherichia coli glutaminyl transfer RNA, synthetase complexed with transfer RNA(Gln) and ATP reveals that the, structure of the anticodon loop of the enzyme-bound tRNA(Gln) differs, extensively from that of the known crystal structures of uncomplexed tRNA, molecules. The anticodon stem is extended by two non-Watson-Crick base, pairs, leaving the three anti-codon bases unpaired and splayed out to bind, snugly into three separate complementary pockets in the protein. These, interactions suggest that the entire anticodon loop provides essential, sites for glutaminyl tRNA synthetase discrimination among tRNA molecules.
+The refined crystal structure of Escherichia coli glutaminyl transfer RNA synthetase complexed with transfer RNA(Gln) and ATP reveals that the structure of the anticodon loop of the enzyme-bound tRNA(Gln) differs extensively from that of the known crystal structures of uncomplexed tRNA molecules. The anticodon stem is extended by two non-Watson-Crick base pairs, leaving the three anti-codon bases unpaired and splayed out to bind snugly into three separate complementary pockets in the protein. These interactions suggest that the entire anticodon loop provides essential sites for glutaminyl tRNA synthetase discrimination among tRNA molecules.
 ==About this Structure==
@@ Line 15: / Line 15: @@
 [[Category: Glutamine--tRNA ligase]]
 [[Category: Single protein]]
-[[Category: Perona, J.J.]]
+[[Category: Perona, J J.]]
-[[Category: Rould, M.A.]]
+[[Category: Rould, M A.]]
-[[Category: Steitz, T.A.]]
+[[Category: Steitz, T A.]]
 [[Category: ATP]]
 [[Category: complex (ligase/trna)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:54:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:53:53 2008''