1hgc: Difference between revisions

Line 4:

==Overview==

The origin of co-operativity in haemoglobin (Hb) resides in the reduced, affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol, can be liganded without the molecule switching to the R high affinity, state. X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has, identified the structural basis for reduced affinity. The nature of the, chemical tension at the haem environment is different in the alpha and, beta haems. There are small but definite structural changes associated, with ligation in the T-state: these prove to be mostly in the same, direction as the larger changes that occur in the T-->R transition.

The origin of co-operativity in haemoglobin (Hb) resides in the reduced affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol can be liganded without the molecule switching to the R high affinity state. X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has identified the structural basis for reduced affinity. The nature of the chemical tension at the haem environment is different in the alpha and beta haems. There are small but definite structural changes associated with ligation in the T-state: these prove to be mostly in the same direction as the larger changes that occur in the T-->R transition.

==Disease==

Line 25:

[[Category: oxygen transport]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 15~~:56:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:59 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 ==Overview==
-The origin of co-operativity in haemoglobin (Hb) resides in the reduced, affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol, can be liganded without the molecule switching to the R high affinity, state. X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has, identified the structural basis for reduced affinity. The nature of the, chemical tension at the haem environment is different in the alpha and, beta haems. There are small but definite structural changes associated, with ligation in the T-state: these prove to be mostly in the same, direction as the larger changes that occur in the T--&gt;R transition.
+The origin of co-operativity in haemoglobin (Hb) resides in the reduced affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol can be liganded without the molecule switching to the R high affinity state. X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has identified the structural basis for reduced affinity. The nature of the chemical tension at the haem environment is different in the alpha and beta haems. There are small but definite structural changes associated with ligation in the T-state: these prove to be mostly in the same direction as the larger changes that occur in the T--&gt;R transition.
 ==Disease==
@@ Line 25: / Line 25: @@
 [[Category: oxygen transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:56:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:59 2008''