1iap: Difference between revisions

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==Overview==

p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a, GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha, subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with, remote sequence identity to RGS (regulators of G protein signaling), domains. The rgRGS domain is necessary but not sufficient for the GAP, activity of p115RhoGEF. The 1.9 A resolution crystal structure of the, rgRGS domain shows structural similarity to RGS domains but possesses a, C-terminal extension that folds into a layer of helices that pack against, the hydrophobic core of the domain. Mutagenesis experiments show that, rgRGS may form interactions with G alpha(13) that are analogous to those, in complexes of RGS proteins with their G alpha substrates.

p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with remote sequence identity to RGS (regulators of G protein signaling) domains. The rgRGS domain is necessary but not sufficient for the GAP activity of p115RhoGEF. The 1.9 A resolution crystal structure of the rgRGS domain shows structural similarity to RGS domains but possesses a C-terminal extension that folds into a layer of helices that pack against the hydrophobic core of the domain. Mutagenesis experiments show that rgRGS may form interactions with G alpha(13) that are analogous to those in complexes of RGS proteins with their G alpha substrates.

==Disease==

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[[Category: Single protein]]

[[Category: Chen, Z.]]

[[Category: Sprang, S.R.]]

[[Category: Sprang, S R.]]

[[Category: p115]]

[[Category: rgrgs]]

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[[Category: rhogef]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:47 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a, GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha, subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with, remote sequence identity to RGS (regulators of G protein signaling), domains. The rgRGS domain is necessary but not sufficient for the GAP, activity of p115RhoGEF. The 1.9 A resolution crystal structure of the, rgRGS domain shows structural similarity to RGS domains but possesses a, C-terminal extension that folds into a layer of helices that pack against, the hydrophobic core of the domain. Mutagenesis experiments show that, rgRGS may form interactions with G alpha(13) that are analogous to those, in complexes of RGS proteins with their G alpha substrates.
+p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with remote sequence identity to RGS (regulators of G protein signaling) domains. The rgRGS domain is necessary but not sufficient for the GAP activity of p115RhoGEF. The 1.9 A resolution crystal structure of the rgRGS domain shows structural similarity to RGS domains but possesses a C-terminal extension that folds into a layer of helices that pack against the hydrophobic core of the domain. Mutagenesis experiments show that rgRGS may form interactions with G alpha(13) that are analogous to those in complexes of RGS proteins with their G alpha substrates.
 ==Disease==
@@ Line 17: / Line 17: @@
 [[Category: Single protein]]
 [[Category: Chen, Z.]]
-[[Category: Sprang, S.R.]]
+[[Category: Sprang, S R.]]
 [[Category: p115]]
 [[Category: rgrgs]]
@@ Line 23: / Line 23: @@
 [[Category: rhogef]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:00:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:47 2008''