1ice: Difference between revisions

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==Overview==

Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor, to the proinflammatory cytokine, interleukin-1 beta, and may regulate, programmed cell death in neuronal cells. The high-resolution structure of, human ICE in complex with an inhibitor has been determined by X-ray, diffraction. The structure confirms the relationship between human ICE and, cell-death proteins in other organisms. The active site spans both the 10, and 20K subunits, which associate to form a tetramer, suggesting a, mechanism for ICE autoactivation.

Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation.

==About this Structure==

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[[Category: Caspases]]

[[Category: Single protein]]

[[Category: Griffith, J.P.]]

[[Category: Griffith, J P.]]

[[Category: Kim, E.E.]]

[[Category: Kim, E E.]]

[[Category: Navia, M.A.]]

[[Category: Navia, M A.]]

[[Category: Wilson, K.P.]]

[[Category: Wilson, K P.]]

[[Category: ACE]]

[[Category: cytokine]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 16~~:00:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:22 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor, to the proinflammatory cytokine, interleukin-1 beta, and may regulate, programmed cell death in neuronal cells. The high-resolution structure of, human ICE in complex with an inhibitor has been determined by X-ray, diffraction. The structure confirms the relationship between human ICE and, cell-death proteins in other organisms. The active site spans both the 10, and 20K subunits, which associate to form a tetramer, suggesting a, mechanism for ICE autoactivation.
+Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Caspases]]
 [[Category: Single protein]]
-[[Category: Griffith, J.P.]]
+[[Category: Griffith, J P.]]
-[[Category: Kim, E.E.]]
+[[Category: Kim, E E.]]
-[[Category: Navia, M.A.]]
+[[Category: Navia, M A.]]
-[[Category: Wilson, K.P.]]
+[[Category: Wilson, K P.]]
 [[Category: ACE]]
 [[Category: cytokine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:00:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:22 2008''