Papain: Difference between revisions

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==='''Cathepsin L (PDB ID #: 1CVZ)'''===

Cathepsin L is another inhibitor of the papain enzyme. Cathepsin L interacts with the <scene name='Sandbox_31/Cathepl/1'>papain residues</scene> Gln19, Cys25, Gly66, Asp158, and Trp177 by hydrogen bonding them (Cathepsin L is lime green in the model, and the papain residues active in hydrogen bonding with Cathepsin L are highlighted with yellow halos). In addition to hydrogen bonding, hydrophobic interactions exist to exclude water, allowing the papain enzyme and Cathepsin L to associate even closer. Finally, <scene name='Sandbox_31/Stacking/1'>Ring Stacking</scene> between Trp177 and the Capthespin L molecule hold them tightly together.<ref>~~http~~:~~//pubs.acs.org/doi/abs/10.1021/ci800085c~~</ref> Cathepsin L plays a roll in many different diseases including malaria, leishmaniasis, Chagas' disease, African trypanosomiasis, toxoplasmosis, and amoebiasis.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923042/?tool=pubmed</ref>Some studies show that there is a relation between cathepsins and certain cancers, alzheimer's, and arthritis.<ref>http://www.biomedcentral.com/1472-6807/10/30</ref>

Cathepsin L is another inhibitor of the papain enzyme. Cathepsin L interacts with the <scene name='Sandbox_31/Cathepl/1'>papain residues</scene> Gln19, Cys25, Gly66, Asp158, and Trp177 by hydrogen bonding them (Cathepsin L is lime green in the model, and the papain residues active in hydrogen bonding with Cathepsin L are highlighted with yellow halos). In addition to hydrogen bonding, hydrophobic interactions exist to exclude water, allowing the papain enzyme and Cathepsin L to associate even closer. Finally, <scene name='Sandbox_31/Stacking/1'>Ring Stacking</scene> between Trp177 and the Capthespin L molecule hold them tightly together.<ref>PMID:18598021</ref> Cathepsin L plays a roll in many different diseases including malaria, leishmaniasis, Chagas' disease, African trypanosomiasis, toxoplasmosis, and amoebiasis.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923042/?tool=pubmed</ref>Some studies show that there is a relation between cathepsins and certain cancers, alzheimer's, and arthritis.<ref>http://www.biomedcentral.com/1472-6807/10/30</ref>

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@@ Line 44: / Line 44: @@
 ==='''Cathepsin L (PDB ID #: 1CVZ)'''===
-Cathepsin L is another inhibitor of the papain enzyme.  Cathepsin L interacts with the <scene name='Sandbox_31/Cathepl/1'>papain residues</scene> Gln19, Cys25, Gly66, Asp158, and Trp177 by hydrogen bonding them (Cathepsin L is lime green in the model, and the papain residues active in hydrogen bonding with Cathepsin L are highlighted with yellow halos). In addition to hydrogen bonding, hydrophobic interactions exist to exclude water, allowing the papain enzyme and Cathepsin L to associate even closer.  Finally, <scene name='Sandbox_31/Stacking/1'>Ring Stacking</scene> between Trp177 and the Capthespin L molecule hold them tightly together.<ref>http://pubs.acs.org/doi/abs/10.1021/ci800085c</ref> Cathepsin L plays a roll in many different diseases including malaria, leishmaniasis, Chagas' disease, African trypanosomiasis, toxoplasmosis, and amoebiasis.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923042/?tool=pubmed</ref>Some studies show that there is a relation between cathepsins and certain cancers, alzheimer's, and arthritis.<ref>http://www.biomedcentral.com/1472-6807/10/30</ref>
+Cathepsin L is another inhibitor of the papain enzyme.  Cathepsin L interacts with the <scene name='Sandbox_31/Cathepl/1'>papain residues</scene> Gln19, Cys25, Gly66, Asp158, and Trp177 by hydrogen bonding them (Cathepsin L is lime green in the model, and the papain residues active in hydrogen bonding with Cathepsin L are highlighted with yellow halos). In addition to hydrogen bonding, hydrophobic interactions exist to exclude water, allowing the papain enzyme and Cathepsin L to associate even closer.  Finally, <scene name='Sandbox_31/Stacking/1'>Ring Stacking</scene> between Trp177 and the Capthespin L molecule hold them tightly together.<ref>PMID:18598021</ref> Cathepsin L plays a roll in many different diseases including malaria, leishmaniasis, Chagas' disease, African trypanosomiasis, toxoplasmosis, and amoebiasis.<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923042/?tool=pubmed</ref>Some studies show that there is a relation between cathepsins and certain cancers, alzheimer's, and arthritis.<ref>http://www.biomedcentral.com/1472-6807/10/30</ref>
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