Papain: Difference between revisions
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==='''Cathepsin L'''=== | ==='''Cathepsin L'''=== | ||
'''Cathepsin L''' is another inhibitor of the papain enzyme. <scene name='Papain/Cathepsin_l/1'>Cathepsin L</scene> interacts with the <scene name='Papain/Cathepsin_l_interaction_w_pap/1'>Papain residues</scene> Gln19, Cys25, Gly66, Asp158, and Trp177 by hydrogen bonding them (Cathepsin L is illustrated in CPK coloring while the interacting sites of Papain are also shown in CPK. In addition to hydrogen bonding, hydrophobic interactions exist to exclude water, allowing the papain enzyme and Cathepsin L to associate even closer. Finally, <scene name=' | '''Cathepsin L''' is another inhibitor of the papain enzyme. <scene name='Papain/Cathepsin_l/1'>Cathepsin L</scene> interacts with the <scene name='Papain/Cathepsin_l_interaction_w_pap/1'>Papain residues</scene> Gln19, Cys25, Gly66, Asp158, and Trp177 by hydrogen bonding them (Cathepsin L is illustrated in CPK coloring while the interacting sites of Papain are also shown in CPK. In addition to hydrogen bonding, hydrophobic interactions exist to exclude water, allowing the papain enzyme and Cathepsin L to associate even closer. Finally, <scene name='Papain/Stacking_cathl/1'>Ring Stacking</scene> between Trp177 and the Capthespin L molecule hold them tightly together.<ref>PMID:18598021</ref> Cathepsin L plays a roll in many different diseases including malaria, leishmaniasis, Chagas' disease, African trypanosomiasis, toxoplasmosis, and amoebiasis. Some studies show that there is a relation between cathepsins and certain cancers, alzheimer's, and arthritis. <ref> PMID:20920298 </ref> | ||
==='''Stefin B'''=== | ==='''Stefin B'''=== | ||
