Thioesterase: Difference between revisions

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'''Thioesterase''' (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group.  TEs are substrate-specific.  Palmitoyl protein TE removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation.  4-hydroxybenzoyl-CoA TE converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA.  Acyl-CoA TE hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism.  Fluoroacetyl-CoA TE from ''Streptomyces cattleya'' hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate.  Ubiquitin TE removes conjugated ubiquitin from proteins thus regulating protein level by preventing their degradation.
'''Thioesterase''' (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group.  TEs are substrate-specific.  '''Palmitoyl protein TE''' removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation.  '''4-hydroxybenzoyl-CoA TE''' converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA.  '''Acyl-CoA TE''' hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism.  '''Fluoroacetyl-CoA TE''' from ''Streptomyces cattleya'' hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate.  '''Ubiquitin TE''' (USP) removes conjugated ubiquitin from proteins thus regulating protein level by preventing their degradation.


==3D structures of thioesterase==
==3D structures of thioesterase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


'''Maristoyl-ACP-specific TE'''
'''Maristoyl-ACP-specific TE'''
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'''Ubiquitin TE'''
'''Ubiquitin TE'''


[[2kzr]] – mTE UBX-like domain – NMR<br />
''USP 2''
[[4dhi]] – CeTE + ubiquitin-conjugating enzyme E2 – ''Caenorhabditis elegans''<br />
 
[[4dhj]], [[4dhz]] – CeTE + ubiquitin-conjugating enzyme E2 + ubiquitin + ubiquitin aldehyde
[[2zfy]] – hUSP – human  <BR />
[[2hd5]], [[3nhe]] – hUSP + Ub  <BR />
[[1tff]] – hUSP (mutant)  <BR />
[[2ibi]] – hUSP (mutant) + Ub <BR />
 
''USP 3''
 
[[2qiy]] – USP + UBP-associated protein – yeast  <BR />
 
''USP 5''
 
[[3ihp]] – hUSP + Ub  <BR />
 
''USP 7''
 
[[2ylm]] – hUSP  <BR />
[[2kvr]] – hUSP UBL domain - NMR <BR />
[[3mqr]], [[3mqs]] – hUSP + peptide <BR />
[[2xxn]] – hUSP + VIRF-4 <BR />
[[4jjq]] – hUSP (mutant) + E2<BR />
 
''USP 8''
 
[[2gwf]] – hUSP rhodanese domain + ring finger protein  <BR />
[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]] – hUSP + SUS1 + SAGA-associated factors 11, 73  <BR />
[[3mhs]] – hUSP + SUS1 + SAGA-associated factors 11, 73 + Ub <BR />
[[3n3k]] – hUSP + Ub inhibitor <BR />
 
''USP 15''
 
[[3lmn]] – hUSP DUSP domain <BR />
 
''USP 16''
 
[[2i50]] – hUSP zinc finger domain - NMR <BR />
 
''USP 21''
 
[[3i3t]] – hUSP + Ub  <BR />
[[3mtn]] – hUSP + Ub inhibitor <BR />
 
''USP 28''
 
[[2lva]] – hUSP N terminal - NMR  <BR />
 
''USP 33''
 
[[2uzg]] – hUSP zinc finger domain - NMR  <BR />
 
''USP 37''
 
[[3ihr]] – hUSP (mutant)  <BR />
[[3a7s]] – hUSP catalytic domain (mutant)  <BR />
 
''USP Cyld''
 
[[2vhf]] – hUSP  <BR />
 
''USP L1''
 
[[3irt]] – hUSP  (mutant) <BR />
[[2len]] – hUSP  (mutant) - NMR<BR />
[[3ifw]], [[3kvf]], [[3kw5]] – hUSP  (mutant) + Ub<BR />
[[4dm9]] – hUSP + peptide inhibitor<BR />
 
''USP L5''
 
[[3ris]] – hUSP catalytic domain  <BR />
[[3rii]] – hUSP catalytic domain (mutant)  <BR />
[[3tb3]] – hUSP UCH domain (mutant)  <BR />
 
''USP ZranB1''
 
[[3zrh]] – hUSP  <BR />
 
''USP OTUB1''
 
[[3von]] – hUSP + E2 <BR />
[[4ddg]], [[4ddi]] – hUSP + Ub<BR />
[[4ddi]] – hUSP (mutant) + Ub<BR />
[[4dhz]] – hUSP + E2 + Ub<BR />
[[4dhj]] – nUSP + E2 + Ub - nematode<BR />
[[4dhi]] – nUSP + E2 <BR />
 
[[3znh]] – USP + Ub – Crimean-Congo hemorrhagic fever virus<BR />


'''RedJ TE'''
'''RedJ TE'''
Retrieved from "https://proteopedia.org/Thioesterase"