2nxb: Difference between revisions
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{{STRUCTURE_2nxb| PDB=2nxb | SCENE= }} | {{STRUCTURE_2nxb| PDB=2nxb | SCENE= }} | ||
===Crystal structure of human Bromodomain containing protein 3 (BRD3)=== | ===Crystal structure of human Bromodomain containing protein 3 (BRD3)=== | ||
{{ABSTRACT_PUBMED_22464331}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022464331</ref><references group="xtra"/> | <ref group="xtra">PMID:022464331</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C.]] | [[Category: Arrowsmith, C.]] | ||