1jwh: Difference between revisions

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==Overview==

The crystal structure of a fully active form of human protein kinase CK2, (casein kinase 2) consisting of two C-terminally truncated catalytic and, two regulatory subunits has been determined at 3.1 A resolution. In the, CK2 complex the regulatory subunits form a stable dimer linking the two, catalytic subunits, which make no direct contact with one another. Each, catalytic subunit interacts with both regulatory chains, predominantly via, an extended C-terminal tail of the regulatory subunit. The CK2 structure, is consistent with its constitutive activity and with a flexible role of, the regulatory subunit as a docking partner for various protein kinases., Furthermore it shows an inter-domain mobility in the catalytic subunit, known to be functionally important in protein kinases and detected here, for the first time directly within one crystal structure.

The crystal structure of a fully active form of human protein kinase CK2 (casein kinase 2) consisting of two C-terminally truncated catalytic and two regulatory subunits has been determined at 3.1 A resolution. In the CK2 complex the regulatory subunits form a stable dimer linking the two catalytic subunits, which make no direct contact with one another. Each catalytic subunit interacts with both regulatory chains, predominantly via an extended C-terminal tail of the regulatory subunit. The CK2 structure is consistent with its constitutive activity and with a flexible role of the regulatory subunit as a docking partner for various protein kinases. Furthermore it shows an inter-domain mobility in the catalytic subunit known to be functionally important in protein kinases and detected here for the first time directly within one crystal structure.

==About this Structure==

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[[Category: Ermakowa, I.]]

[[Category: Guerra, B.]]

[[Category: Issinger, O.G.]]

[[Category: Issinger, O G.]]

[[Category: Niefind, K.]]

[[Category: ANP]]

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[[Category: protein kinase ck2]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:27:29 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of a fully active form of human protein kinase CK2, (casein kinase 2) consisting of two C-terminally truncated catalytic and, two regulatory subunits has been determined at 3.1 A resolution. In the, CK2 complex the regulatory subunits form a stable dimer linking the two, catalytic subunits, which make no direct contact with one another. Each, catalytic subunit interacts with both regulatory chains, predominantly via, an extended C-terminal tail of the regulatory subunit. The CK2 structure, is consistent with its constitutive activity and with a flexible role of, the regulatory subunit as a docking partner for various protein kinases., Furthermore it shows an inter-domain mobility in the catalytic subunit, known to be functionally important in protein kinases and detected here, for the first time directly within one crystal structure.
+The crystal structure of a fully active form of human protein kinase CK2 (casein kinase 2) consisting of two C-terminally truncated catalytic and two regulatory subunits has been determined at 3.1 A resolution. In the CK2 complex the regulatory subunits form a stable dimer linking the two catalytic subunits, which make no direct contact with one another. Each catalytic subunit interacts with both regulatory chains, predominantly via an extended C-terminal tail of the regulatory subunit. The CK2 structure is consistent with its constitutive activity and with a flexible role of the regulatory subunit as a docking partner for various protein kinases. Furthermore it shows an inter-domain mobility in the catalytic subunit known to be functionally important in protein kinases and detected here for the first time directly within one crystal structure.
 ==About this Structure==
@@ Line 16: / Line 16: @@
 [[Category: Ermakowa, I.]]
 [[Category: Guerra, B.]]
-[[Category: Issinger, O.G.]]
+[[Category: Issinger, O G.]]
 [[Category: Niefind, K.]]
 [[Category: ANP]]
@@ Line 25: / Line 25: @@
 [[Category: protein kinase ck2]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:09:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:27:29 2008''