1jy1: Difference between revisions

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==Overview==

Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of a, phosphodiester bond between a tyrosine residue and a DNA 3' phosphate. The, enzyme appears to be responsible for repairing the unique protein-DNA, linkage that occurs when eukaryotic topoisomerase I becomes stalled on the, DNA in the cell. The 1.69 A crystal structure reveals that human Tdp1 is a, monomer composed of two similar domains that are related by a, pseudo-2-fold axis of symmetry. Each domain contributes conserved, histidine, lysine, and asparagine residues to form a single active site., The structure of Tdp1 confirms that the protein has many similarities to, the members of the phospholipase D (PLD) superfamily and indicates a, similar catalytic mechanism. The structure also suggests how the unusual, protein-DNA substrate binds and provides insights about the nature of the, substrate in vivo.

Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of a phosphodiester bond between a tyrosine residue and a DNA 3' phosphate. The enzyme appears to be responsible for repairing the unique protein-DNA linkage that occurs when eukaryotic topoisomerase I becomes stalled on the DNA in the cell. The 1.69 A crystal structure reveals that human Tdp1 is a monomer composed of two similar domains that are related by a pseudo-2-fold axis of symmetry. Each domain contributes conserved histidine, lysine, and asparagine residues to form a single active site. The structure of Tdp1 confirms that the protein has many similarities to the members of the phospholipase D (PLD) superfamily and indicates a similar catalytic mechanism. The structure also suggests how the unusual protein-DNA substrate binds and provides insights about the nature of the substrate in vivo.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Champoux, J.J.]]

[[Category: Champoux, J J.]]

[[Category: Davies, D.R.]]

[[Category: Davies, D R.]]

[[Category: Hol, W.G.J.]]

[[Category: Hol, W G.J.]]

[[Category: Interthal, H.]]

[[Category: pld superfamily]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of a, phosphodiester bond between a tyrosine residue and a DNA 3' phosphate. The, enzyme appears to be responsible for repairing the unique protein-DNA, linkage that occurs when eukaryotic topoisomerase I becomes stalled on the, DNA in the cell. The 1.69 A crystal structure reveals that human Tdp1 is a, monomer composed of two similar domains that are related by a, pseudo-2-fold axis of symmetry. Each domain contributes conserved, histidine, lysine, and asparagine residues to form a single active site., The structure of Tdp1 confirms that the protein has many similarities to, the members of the phospholipase D (PLD) superfamily and indicates a, similar catalytic mechanism. The structure also suggests how the unusual, protein-DNA substrate binds and provides insights about the nature of the, substrate in vivo.
+Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of a phosphodiester bond between a tyrosine residue and a DNA 3' phosphate. The enzyme appears to be responsible for repairing the unique protein-DNA linkage that occurs when eukaryotic topoisomerase I becomes stalled on the DNA in the cell. The 1.69 A crystal structure reveals that human Tdp1 is a monomer composed of two similar domains that are related by a pseudo-2-fold axis of symmetry. Each domain contributes conserved histidine, lysine, and asparagine residues to form a single active site. The structure of Tdp1 confirms that the protein has many similarities to the members of the phospholipase D (PLD) superfamily and indicates a similar catalytic mechanism. The structure also suggests how the unusual protein-DNA substrate binds and provides insights about the nature of the substrate in vivo.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Champoux, J.J.]]
+[[Category: Champoux, J J.]]
-[[Category: Davies, D.R.]]
+[[Category: Davies, D R.]]
-[[Category: Hol, W.G.J.]]
+[[Category: Hol, W G.J.]]
 [[Category: Interthal, H.]]
 [[Category: pld superfamily]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:10:18 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:28:00 2008''