1k9j: Difference between revisions

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==Overview==

Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3), grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of, dendritic cells, mediates the initial interaction of dendritic cells with, T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor, found on the endothelium of liver sinusoids, placental capillaries, and, lymph nodes, bind to oligosaccharides that are present on the envelope of, human immunodeficiency virus (HIV), an interaction that strongly promotes, viral infection of T cells. Crystal structures of carbohydrate-recognition, domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in, combination with binding studies, reveal that these receptors selectively, recognize endogenous high-mannose oligosaccharides and may represent a new, avenue for developing HIV prophylactics.

Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.

==Disease==

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[[Category: Drickamer, K.]]

[[Category: Feinberg, H.]]

[[Category: Mitchell, D.A.]]

[[Category: Mitchell, D A.]]

[[Category: Weis, W.I.]]

[[Category: Weis, W I.]]

[[Category: CA]]

[[Category: c-type lectin]]

[[Category: protein carbohydrate complex]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:31:38 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3), grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of, dendritic cells, mediates the initial interaction of dendritic cells with, T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor, found on the endothelium of liver sinusoids, placental capillaries, and, lymph nodes, bind to oligosaccharides that are present on the envelope of, human immunodeficiency virus (HIV), an interaction that strongly promotes, viral infection of T cells. Crystal structures of carbohydrate-recognition, domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in, combination with binding studies, reveal that these receptors selectively, recognize endogenous high-mannose oligosaccharides and may represent a new, avenue for developing HIV prophylactics.
+Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.
 ==Disease==
@@ Line 18: / Line 18: @@
 [[Category: Drickamer, K.]]
 [[Category: Feinberg, H.]]
-[[Category: Mitchell, D.A.]]
+[[Category: Mitchell, D A.]]
-[[Category: Weis, W.I.]]
+[[Category: Weis, W I.]]
 [[Category: CA]]
 [[Category: c-type lectin]]
 [[Category: protein carbohydrate complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:12:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:31:38 2008''