Sandbox Reserved 489: Difference between revisions
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Renin has been identified in many eukaryotic organisms including; humans, mice, marmosets, monkeys, chimpanzees, macaques, dogs, rats, frogs, and zebrafish. The function of renin in all organisms is similar, but the sequence and peptide length vary slightly. | Renin has been identified in many eukaryotic organisms including; humans, mice, marmosets, monkeys, chimpanzees, macaques, dogs, rats, frogs, and zebrafish. The function of renin in all organisms is similar, but the sequence and peptide length vary slightly. | ||
Renin is important clinically because [http://en.wikipedia.org/wiki/Renin_inhibitor renin inhibitors], such as [http://en.wikipedia.org/wiki/Aliskiren Aliskiren] can be used to treat hypertension. | Renin is important clinically because [http://en.wikipedia.org/wiki/Renin_inhibitor renin inhibitors], such as [http://en.wikipedia.org/wiki/Aliskiren Aliskiren], can be used to treat hypertension. | ||
==Structure== | ==Structure== | ||
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The structure of renin bound with the inhibitor Aliskiren has been solved using X-ray diffraction at 3.0 Å resolution.<ref>PMID: 10903938</ref> | The structure of renin bound with the inhibitor Aliskiren has been solved using X-ray diffraction at 3.0 Å resolution.<ref>PMID: 10903938</ref> | ||
