4dep: Difference between revisions

Line 1:

[[~~Image~~:~~4dep~~.~~png~~|~~left~~|~~200px~~]]

==Structure of the IL-1b signaling complex==

== Structural highlights ==

<table><tr><td colspan='2'>[[4dep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DEP FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>

<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL-1b, IL1B, IL1F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL-1RI, IL1R, IL1R1, IL1RA, IL1RT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), C3orf13, IL-1RAcP, IL1R3, IL1RAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dep RCSB], [http://www.ebi.ac.uk/pdbsum/4dep PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1beta bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.

<!--

Structure of the activating IL-1 receptor signaling complex.,Thomas C, Bazan JF, Garcia KC Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260. PMID:22426547<ref>PMID:22426547</ref>

~~The line below this paragraph~~, ~~containing "STRUCTURE_4dep"~~, ~~creates the "Structure Box" on the page~~.

~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display~~.

-->

~~{{STRUCTURE_4dep| PDB=4dep | SCENE= }}~~

~~===Structure~~ of the ~~IL-1b signaling complex===~~

From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>

</div>

==See Also==

~~<!--~~

*[[Interleukin|Interleukin]]

~~The line below this paragraph, {{ABSTRACT_PUBMED_22426547}}, adds the Publication Abstract to the page~~

*[[Interleukin receptor|Interleukin receptor]]

~~(as it appears on PubMed at http://www.pubmed.gov), where 22426547 is the PubMed ID number.~~

== References ==

~~-->~~

~~{{ABSTRACT_PUBMED_22426547}}~~

__TOC__

</StructureSection>

==~~About this Structure~~==

[[~~4dep~~]] ~~is a 6 chain structure with sequence from~~ [~~http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEP OCA~~].

==~~Reference~~==

<~~ref group="xtra">PMID:022426547<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Homo sapiens]]

[[Category: Garcia, K C.]]

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@@ Line 1: / Line 1: @@
-[[Image:4dep.png|left|200px]]
+==Structure of the IL-1b signaling complex==
+<StructureSection load='4dep' size='340' side='right' caption='[[4dep]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4dep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DEP FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL-1b, IL1B, IL1F2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL-1RI, IL1R, IL1R1, IL1RA, IL1RT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), C3orf13, IL-1RAcP, IL1R3, IL1RAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dep RCSB], [http://www.ebi.ac.uk/pdbsum/4dep PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1beta bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.
-<!--
+Structure of the activating IL-1 receptor signaling complex.,Thomas C, Bazan JF, Garcia KC Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260. PMID:22426547<ref>PMID:22426547</ref>
-The line below this paragraph, containing "STRUCTURE_4dep", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_4dep|  PDB=4dep  |  SCENE=  }}
-===Structure of the IL-1b signaling complex===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
+==See Also==
-<!--
+*[[Interleukin|Interleukin]]
-The line below this paragraph, {{ABSTRACT_PUBMED_22426547}}, adds the Publication Abstract to the page
+*[[Interleukin receptor|Interleukin receptor]]
-(as it appears on PubMed at http://www.pubmed.gov), where 22426547 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_22426547}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4dep]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DEP OCA].
-==Reference==
-<ref group="xtra">PMID:022426547</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
 [[Category: Garcia, K C.]]