Interferon: Difference between revisions

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<StructureSection load='2hym' size='500' side='right' caption='Click on the green links to the left to view the structural aspects of interferons. PDB ID: [[2hym]])' scene='Interferons/Interferonaandreceptor/2'>
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==Interferon-β==
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<scene name='Multiple_sclerosis/Interferon_beta/9'>Interferon-β</scene> is a protein growth factor that stimulates an antiviral defense. Its encoding gene is one of only two known vertebrate structural genes that lacks introns.<ref name="Biochem Text">Voet, D., Voet, J.G., and C. Pratt. ''Fundamentals of Biochemistry'' 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.</ref>
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Interferon-β is a relatively simple biological response modifier, with several <scene name='Multiple_sclerosis/Interferon_beta_labeled/1'>identifiable regions</scene>. It consists of five <scene name='Multiple_sclerosis/Ifnb_helices_in_color/1'>alpha helices</scene>, as well as multiple interconnecting <scene name='Multiple_sclerosis/Interferon_beta_loops/2'>loop regions</scene>. Helices A, B and D run <scene name='Multiple_sclerosis/Ifnb_parallel_abd/3'>parallel to one another</scene>, and helices C and E run <scene name='Multiple_sclerosis/Ifnb_antiparallel/1'>anti-parallel</scene> to the other three helices, but <scene name='Multiple_sclerosis/Ifnb_antiparallel_ce/3'>parallel</scene> to one another. Helix A consists of residues 6-23; Helix B consists of residues 49-65; Helix C consists of residues 77-91; Helix D consists of residues 112-131; and Helix E consists of residues 135-155.<ref name="Structure Ifn B">PMID:20616576</ref><ref name="UniProt">http://www.uniprot.org/uniprot/P00784</ref>
 
 
==Interferon-α==
 
==Interferon-γ==
</StructureSection>
=== A comparative representation of three interferons ===
=== A comparative representation of three interferons ===
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|<applet load='1ITF.pdb' name='A' size='300' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Interferons/Ifn_alpha/4'/>
|<applet load='1ITF.pdb' name='A' size='300' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Interferons/Ifn_alpha/4'/>
|<applet load='1IFA.pdb' name='B' size='300' frame='true' align='right' caption='Interferon Beta' align='left' scene='Interferons/Interferon_beta/3'/>
|<applet load='1IFA.pdb' name='B' size='300' frame='true' align='right' caption='Interferon Beta' align='left' scene='Interferons/Interferon_beta/3'/>
|<applet load='1HIG.pdb' name='Z' size='300' frame='true' align='right' caption='Interferon Gamma' align='left' scene='Interferons/Ifn_gamma/3'/>
|<applet load='1HIG.pdb' name='Z' size='300' frame='true' align='right' caption='Interferon Gamma' align='left' scene='Interferons/Ifn_gamma/3'/>|
|}
|}


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