Multiple sclerosis: Difference between revisions
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[[Image:MSLesions.jpg|450px|right|thumb|Courtesy of Intermountain Medical Imaging, Boise, Idaho.<ref>[http://www.health.com/health/library/mdp/0,,zm6056,00.html] Poinier, A.C., Husney, A., and Chalk, C. "Magnetic resonance imaging (MRI) of multiple sclerosis." ''Health.com'' Updated: 2010 Feb 18.</ref>]] | |||
'''Multiple sclerosis (MS)''' - an autoimmune disease that effects every patient differently based on the neurologic lesions inflicted throughout the body. While some can go through their lives with relatively mild symptoms and short periods of relapse, others can become incapacitated within years or even months. Defined by Nylander and Hafler, MS is a "multifocal demyelinating disease with progressive neurodegeneration caused by an autoimmune response to self-antigens in a genetically susceptible individual."<ref name ="MS Nylander & Hafler">PMID:22466660</ref> Inflammation is the primary cause of damage in MS, and though the effects of the disease are well known, and various treatments exist for the disease, the exact identity of an antigen or infectious agent that causes the initiation of a myriad of symptoms is unknown.<ref name='MS:Pathogenesis and Treatment'>PMID:22379455</ref> | '''Multiple sclerosis (MS)''' - an autoimmune disease that effects every patient differently based on the neurologic lesions inflicted throughout the body. While some can go through their lives with relatively mild symptoms and short periods of relapse, others can become incapacitated within years or even months. Defined by Nylander and Hafler, MS is a "multifocal demyelinating disease with progressive neurodegeneration caused by an autoimmune response to self-antigens in a genetically susceptible individual."<ref name ="MS Nylander & Hafler">PMID:22466660</ref> Inflammation is the primary cause of damage in MS, and though the effects of the disease are well known, and various treatments exist for the disease, the exact identity of an antigen or infectious agent that causes the initiation of a myriad of symptoms is unknown.<ref name='MS:Pathogenesis and Treatment'>PMID:22379455</ref> | ||
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Taking a biochemical look at the immunopathology and some of the various treatments that exist for MS helps in the understanding that MS is no longer a diagnosis which is hopeless, but is in fact full of hopeful and helpful treatments. | Taking a biochemical look at the immunopathology and some of the various treatments that exist for MS helps in the understanding that MS is no longer a diagnosis which is hopeless, but is in fact full of hopeful and helpful treatments. | ||
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<StructureSection load='1tcr' size='500' side='right' caption='Click on the green links to the left to observe the various proteins involved in MS immunopathology (PDB entry: [[1tcr]])' scene='Multiple_sclerosis/Ifnawithreceptor/1'> | <StructureSection load='1tcr' size='500' side='right' caption='Click on the green links to the left to observe the various proteins involved in MS immunopathology (PDB entry: [[1tcr]])' scene='Multiple_sclerosis/Ifnawithreceptor/1'> | ||
