1lpe: Difference between revisions

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==Overview==

Human apolipoprotein E, a blood plasma protein, mediates the transport and, uptake of cholesterol and lipid by way of its high affinity interaction, with different cellular receptors, including the low-density lipoprotein, (LDL) receptor. The three-dimensional structure of the LDL, receptor-binding domain of apoE has been determined at 2.5 angstrom, resolution by x-ray crystallography. The protein forms an unusually, elongated (65 angstroms) four-helix bundle, with the helices apparently, stabilized by a tightly packed hydrophobic core that includes leucine, zipper-type interactions and by numerous salt bridges on the mostly, charged surface. Basic amino acids important for LDL receptor binding are, clustered into a surface patch on one long helix. This structure provides, the basis for understanding the behavior of naturally occurring mutants, that can lead to atherosclerosis.

Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. The three-dimensional structure of the LDL receptor-binding domain of apoE has been determined at 2.5 angstrom resolution by x-ray crystallography. The protein forms an unusually elongated (65 angstroms) four-helix bundle, with the helices apparently stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix. This structure provides the basis for understanding the behavior of naturally occurring mutants that can lead to atherosclerosis.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Agard, D.A.]]

[[Category: Agard, D A.]]

[[Category: Wilson, C.]]

[[Category: lipoprotein]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:47:06 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Human apolipoprotein E, a blood plasma protein, mediates the transport and, uptake of cholesterol and lipid by way of its high affinity interaction, with different cellular receptors, including the low-density lipoprotein, (LDL) receptor. The three-dimensional structure of the LDL, receptor-binding domain of apoE has been determined at 2.5 angstrom, resolution by x-ray crystallography. The protein forms an unusually, elongated (65 angstroms) four-helix bundle, with the helices apparently, stabilized by a tightly packed hydrophobic core that includes leucine, zipper-type interactions and by numerous salt bridges on the mostly, charged surface. Basic amino acids important for LDL receptor binding are, clustered into a surface patch on one long helix. This structure provides, the basis for understanding the behavior of naturally occurring mutants, that can lead to atherosclerosis.
+Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. The three-dimensional structure of the LDL receptor-binding domain of apoE has been determined at 2.5 angstrom resolution by x-ray crystallography. The protein forms an unusually elongated (65 angstroms) four-helix bundle, with the helices apparently stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix. This structure provides the basis for understanding the behavior of naturally occurring mutants that can lead to atherosclerosis.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Agard, D.A.]]
+[[Category: Agard, D A.]]
 [[Category: Wilson, C.]]
 [[Category: lipoprotein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:19:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:47:06 2008''