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[[Image:3zrm.png|left|200px]]
==Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors==
<StructureSection load='3zrm' size='340' side='right' caption='[[3zrm]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3zrm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZRM FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRM:7-(4-HYDROXYPHENYL)-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE'>ZRM</scene><br>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2uw9|2uw9]], [[1o6k|1o6k]], [[1h8f|1h8f]], [[1gng|1gng]], [[1q3w|1q3w]], [[3zrk|3zrk]], [[1i09|1i09]], [[2x37|2x37]], [[1o9u|1o9u]], [[1o6l|1o6l]], [[2jdr|2jdr]], [[1j1b|1j1b]], [[1r0e|1r0e]], [[1q41|1q41]], [[2x39|2x39]], [[1q3d|1q3d]], [[2jld|2jld]], [[1q5k|1q5k]], [[2jdo|2jdo]], [[1pyx|1pyx]], [[1q4l|1q4l]], [[1j1c|1j1c]], [[2xh5|2xh5]], [[1uv5|1uv5]], [[3zrl|3zrl]]</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zrm RCSB], [http://www.ebi.ac.uk/pdbsum/3zrm PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3beta inhibitors is reported. X-ray crystallography reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented.


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Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors.,Gentile G, Bernasconi G, Pozzan A, Merlo G, Marzorati P, Bamborough P, Bax B, Bridges A, Brough C, Carter P, Cutler G, Neu M, Takada M Bioorg Med Chem Lett. 2011 Aug 15;21(16):4823-7. Epub 2011 Jun 29. PMID:21764580<ref>PMID:21764580</ref>
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{{STRUCTURE_3zrm|  PDB=3zrm  |  SCENE=  }}


===Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


 
==See Also==
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*[[Glycogen synthase kinase 3|Glycogen synthase kinase 3]]
The line below this paragraph, {{ABSTRACT_PUBMED_21764580}}, adds the Publication Abstract to the page
== References ==
(as it appears on PubMed at http://www.pubmed.gov), where 21764580 is the PubMed ID number.
<references/>
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{{ABSTRACT_PUBMED_21764580}}
</StructureSection>
 
==About this Structure==
[[3zrm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRM OCA].
 
==Reference==
<ref group="xtra">PMID:021764580</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bamborough, P.]]
[[Category: Bamborough, P.]]

Revision as of 07:36, 5 June 2014

Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors

3zrm, resolution 2.49Å

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