3axc: Difference between revisions

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[[~~Image~~:~~3axc~~.~~png~~|~~left~~|~~200px~~]]

==Crystal structure of linear diubiquitin==

== Structural highlights ==

<table><tr><td colspan='2'>[[3axc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AXC FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>

<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3axc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3axc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3axc RCSB], [http://www.ebi.ac.uk/pdbsum/3axc PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Post-translational modifications involving ubiquitin regulate a wide range of biological processes including protein degradation, responses to DNA damage and immune signalling. Ubiquitin polymerizes into chains which may contain eight different linkage types; the ubiquitin C-terminal glycine can link to one of the seven lysine residues or the N-terminal amino group of methionine in the distal ubiquitin molecule. The latter head-to-tail linkage type, referred to as a linear ubiquitin chain, is involved in NF-kappaB activation through specific interactions with NF-kappaB essential modulator (NEMO). Here, a crystal structure of linear diubiquitin at a resolution of 2.2 A is reported. Although the two ubiquitin moieties do not interact with each other directly, the overall structure adopts a compact but not completely closed conformation with a few intermoiety contacts. This structure differs from the previously reported extended conformation, which resembles Lys63-linked diubiquitin, suggesting that the linear polyubiquitin chain is intrinsically flexible and can adopt multiple conformations.

~~<!--~~

Structure of a compact conformation of linear diubiquitin.,Rohaim A, Kawasaki M, Kato R, Dikic I, Wakatsuki S Acta Crystallogr D Biol Crystallogr. 2012 Feb;68(Pt 2):102-8. Epub 2012 Jan 13. PMID:22281738<ref>PMID:22281738</ref>

~~The line below this paragraph~~, ~~containing "STRUCTURE_3axc"~~, ~~creates the "Structure Box" on the page~~.

~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display~~.

-->

~~{{STRUCTURE_3axc| PDB=3axc | SCENE= }}~~

~~===Crystal structure~~ of ~~linear diubiquitin===~~

From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

~~<!--~~

~~The line below this paragraph, {{ABSTRACT_PUBMED_22281738}}, adds the Publication Abstract to~~ the ~~page~~

__TOC__

~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22281738 is the PubMed ID number~~.

</StructureSection>

-->

~~{{ABSTRACT_PUBMED_22281738}}~~

~~==About this Structure==~~

~~[[3axc]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AXC OCA].~~

==~~Reference~~==

<~~ref group="xtra">PMID:022281738<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Homo sapiens]]

[[Category: Dikic, I.]]

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@@ Line 1: / Line 1: @@
-[[Image:3axc.png|left|200px]]
+==Crystal structure of linear diubiquitin==
+<StructureSection load='3axc' size='340' side='right' caption='[[3axc]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3axc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AXC FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RPS27A, UBA80, UBCEP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3axc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3axc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3axc RCSB], [http://www.ebi.ac.uk/pdbsum/3axc PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Post-translational modifications involving ubiquitin regulate a wide range of biological processes including protein degradation, responses to DNA damage and immune signalling. Ubiquitin polymerizes into chains which may contain eight different linkage types; the ubiquitin C-terminal glycine can link to one of the seven lysine residues or the N-terminal amino group of methionine in the distal ubiquitin molecule. The latter head-to-tail linkage type, referred to as a linear ubiquitin chain, is involved in NF-kappaB activation through specific interactions with NF-kappaB essential modulator (NEMO). Here, a crystal structure of linear diubiquitin at a resolution of 2.2 A is reported. Although the two ubiquitin moieties do not interact with each other directly, the overall structure adopts a compact but not completely closed conformation with a few intermoiety contacts. This structure differs from the previously reported extended conformation, which resembles Lys63-linked diubiquitin, suggesting that the linear polyubiquitin chain is intrinsically flexible and can adopt multiple conformations.
-<!--
+Structure of a compact conformation of linear diubiquitin.,Rohaim A, Kawasaki M, Kato R, Dikic I, Wakatsuki S Acta Crystallogr D Biol Crystallogr. 2012 Feb;68(Pt 2):102-8. Epub 2012 Jan 13. PMID:22281738<ref>PMID:22281738</ref>
-The line below this paragraph, containing "STRUCTURE_3axc", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_3axc|  PDB=3axc  |  SCENE=  }}
-===Crystal structure of linear diubiquitin===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_22281738}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 22281738 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_22281738}}
-==About this Structure==
-[[3axc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AXC OCA].
-==Reference==
-<ref group="xtra">PMID:022281738</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
 [[Category: Dikic, I.]]