1mh1: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
The crystal structure of human rac1, a member of the rho family of small | The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family. | ||
==About this Structure== | ==About this Structure== | ||
| Line 15: | Line 15: | ||
[[Category: Dodson, G.]] | [[Category: Dodson, G.]] | ||
[[Category: Hirshberg, M.]] | [[Category: Hirshberg, M.]] | ||
[[Category: Stockley, R | [[Category: Stockley, R W.]] | ||
[[Category: Webb, M | [[Category: Webb, M R.]] | ||
[[Category: GNP]] | [[Category: GNP]] | ||
[[Category: MG]] | [[Category: MG]] | ||
| Line 25: | Line 25: | ||
[[Category: small g-protein]] | [[Category: small g-protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:55:05 2008'' | ||
Revision as of 11:55, 21 February 2008
|
SMALL G-PROTEIN
Overview
The crystal structure of human rac1, a member of the rho family of small G-proteins, complexed with the non-hydrolysable GTP analogue, guanosine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 A. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical domain that is characteristic of the rho G proteins, and may be involved in the signalling pathway of this family.
About this Structure
1MH1 is a Single protein structure of sequence from Homo sapiens with MG and GNP as ligands. Full crystallographic information is available from OCA.
Reference
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue., Hirshberg M, Stockley RW, Dodson G, Webb MR, Nat Struct Biol. 1997 Feb;4(2):147-52. PMID:9033596
Page seeded by OCA on Thu Feb 21 13:55:05 2008
