1mq9: Difference between revisions

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==Overview==

The structure of the I domain of integrin alpha L beta 2 bound to the Ig, superfamily ligand ICAM-1 reveals the open ligand binding conformation and, the first example of an integrin-IgSF interface. The I domain Mg2+, directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain, residue Glu-241 enables a critical salt bridge. Liganded and unliganded, structures for both high- and intermediate-affinity mutant I domains, reveal that ligand binding can induce conformational change in the alpha L, I domain and that allosteric signals can convert the closed conformation, to intermediate or open conformations without ligand binding. Pulling down, on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets, the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in, affinity.

The structure of the I domain of integrin alpha L beta 2 bound to the Ig superfamily ligand ICAM-1 reveals the open ligand binding conformation and the first example of an integrin-IgSF interface. The I domain Mg2+ directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain residue Glu-241 enables a critical salt bridge. Liganded and unliganded structures for both high- and intermediate-affinity mutant I domains reveal that ligand binding can induce conformational change in the alpha L I domain and that allosteric signals can convert the closed conformation to intermediate or open conformations without ligand binding. Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity.

==About this Structure==

Line 15:

[[Category: Dong, Y.]]

[[Category: Joachimiak, A.]]

[[Category: Jun, C.D.]]

[[Category: Jun, C D.]]

[[Category: Liu, J.H.]]

[[Category: Liu, J H.]]

[[Category: McCormack, A.]]

[[Category: Shimaoka, M.]]

[[Category: Springer, T.A.]]

[[Category: Springer, T A.]]

[[Category: Takagi, J.]]

[[Category: Wang, J.H.]]

[[Category: Wang, J H.]]

[[Category: Xiao, T.]]

[[Category: Yang, Y.]]

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[[Category: rossmann fold]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:53 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The structure of the I domain of integrin alpha L beta 2 bound to the Ig, superfamily ligand ICAM-1 reveals the open ligand binding conformation and, the first example of an integrin-IgSF interface. The I domain Mg2+, directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain, residue Glu-241 enables a critical salt bridge. Liganded and unliganded, structures for both high- and intermediate-affinity mutant I domains, reveal that ligand binding can induce conformational change in the alpha L, I domain and that allosteric signals can convert the closed conformation, to intermediate or open conformations without ligand binding. Pulling down, on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets, the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in, affinity.
+The structure of the I domain of integrin alpha L beta 2 bound to the Ig superfamily ligand ICAM-1 reveals the open ligand binding conformation and the first example of an integrin-IgSF interface. The I domain Mg2+ directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain residue Glu-241 enables a critical salt bridge. Liganded and unliganded structures for both high- and intermediate-affinity mutant I domains reveal that ligand binding can induce conformational change in the alpha L I domain and that allosteric signals can convert the closed conformation to intermediate or open conformations without ligand binding. Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity.
 ==About this Structure==
@@ Line 15: / Line 15: @@
 [[Category: Dong, Y.]]
 [[Category: Joachimiak, A.]]
-[[Category: Jun, C.D.]]
+[[Category: Jun, C D.]]
-[[Category: Liu, J.H.]]
+[[Category: Liu, J H.]]
 [[Category: McCormack, A.]]
 [[Category: Shimaoka, M.]]
-[[Category: Springer, T.A.]]
+[[Category: Springer, T A.]]
 [[Category: Takagi, J.]]
-[[Category: Wang, J.H.]]
+[[Category: Wang, J H.]]
 [[Category: Xiao, T.]]
 [[Category: Yang, Y.]]
@@ Line 30: / Line 30: @@
 [[Category: rossmann fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:25:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:53 2008''