Sandbox Reserved 452: Difference between revisions
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== Introduction == | == Introduction == | ||
C-Myc is a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor] involved in the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle] specifically with the stimulation of cell proliferation but is also involved in the regulation of [http://en.wikipedia.org/wiki/Apoptosis apoptosis], [http://en.wikipedia.org/wiki/Cell_differentiation cell differentiation], cell competition, and [http://en.wikipedia.org/wiki/Senescence senescence] <ref>PMID:22510570</ref>. C-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein] and functions primarily by inducing transcription through the formation of [http://en.wikipedia.org/wiki/Protein_dimer heterodimers] primarily with [http://en.wikipedia.org/wiki/MAX_(gene) Max proteins]. C-Myc's interactions are not limited to only Max protiens as it has been shown to interact with [http://en.wikipedia.org/wiki/BRCA1 BRCA1]<ref>PMID:9788437</ref>, [http://en.wikipedia.org/wiki/Mapk1 MAPK1]<ref>PMID: 7957875</ref>, [http://en.wikipedia.org/wiki/P73 p73]<ref>PMID:11844794</ref>, and many more. C-Myc is also a [http://en.wikipedia.org/wiki/Oncogene protooncogene], and when normally expressed is strictly regulated by signals within the cell cycle, so that when a cell is resting its c-myc expression is little while when growing it expresses high levels of c-myc. When normal cells overexpression of c-myc activates a protection pathway and the abnormal cells are thus eliminated from the host organism through apoptosis, thus protecting the organism. | C-Myc is a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor] involved in the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle] specifically with the stimulation of cell proliferation but is also involved in the regulation of [http://en.wikipedia.org/wiki/Apoptosis apoptosis], [http://en.wikipedia.org/wiki/Cell_differentiation cell differentiation], cell competition, and [http://en.wikipedia.org/wiki/Senescence senescence] <ref>PMID:22510570</ref>. C-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein] and functions primarily by inducing transcription through the formation of [http://en.wikipedia.org/wiki/Protein_dimer heterodimers] primarily with [http://en.wikipedia.org/wiki/MAX_(gene) Max proteins]. C-Myc's interactions are not limited to only Max protiens as it has been shown to interact with [http://en.wikipedia.org/wiki/BRCA1 BRCA1]<ref>PMID:9788437</ref>, [http://en.wikipedia.org/wiki/Mapk1 MAPK1]<ref>PMID: 7957875</ref>, [http://en.wikipedia.org/wiki/P73 p73]<ref>PMID:11844794</ref>, and many more. C-Myc is also a [http://en.wikipedia.org/wiki/Oncogene protooncogene], and when normally expressed is strictly regulated by signals within the cell cycle, so that when a cell is resting its c-myc expression is little while when growing it expresses high levels of c-myc. When normal cells overexpression of c-myc activates a protection pathway and the abnormal cells are thus eliminated from the host organism through apoptosis, thus protecting the organism. | ||
== Structure == | == Structure == | ||
The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper motif and an amino terminal transactivation domain<ref>PMID:8193530</ref>. Immediatley following the basic region within the c-myc protein is the helix -loop-helix motif which has been shown to interact with DNA through binding <ref>PMID:8193530</ref>. The c-myc gene is essientially found on human chromosome 8q24 and contains three exons. | The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper motif and an amino terminal transactivation domain<ref>PMID:8193530</ref>. Immediatley following the basic region within the c-myc protein is the helix -loop-helix motif which has been shown to interact with DNA through binding <ref>PMID:8193530</ref>. The c-myc gene is essientially found on human chromosome 8q24 and contains three exons. | ||
== Medical Uses and Therapeutic Opportunities == | == Medical Uses and Therapeutic Opportunities == | ||
