Sandbox Reserved 468: Difference between revisions
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Research has shown that MMP-1 may have many medical implications. MMP-1 plays an important role in many physiologic processes such as development, tissue morphogenesis, wound repair and the remodeling of collagenous extracellular matrix. The enzyme is expressed by over 30 different cells. Collagen serves as a structural scaffold and a barrier between tissues, and thus collagen catabolism (collagenolysis) is required to be a tightly regulated process in normal physiology. In turn, the destruction or damage of collagen during pathological states plays a role in tumor growth and invasion, cartilage degradation, or atherosclerotic plaque formation and rupture [4]. | Research has shown that MMP-1 may have many medical implications. MMP-1 plays an important role in many physiologic processes such as development, tissue morphogenesis, wound repair and the remodeling of collagenous extracellular matrix. The enzyme is expressed by over 30 different cells. Collagen serves as a structural scaffold and a barrier between tissues, and thus collagen catabolism (collagenolysis) is required to be a tightly regulated process in normal physiology. In turn, the destruction or damage of collagen during pathological states plays a role in tumor growth and invasion, cartilage degradation, or atherosclerotic plaque formation and rupture [4]. | ||
[[Image:mmp_cells.jpg]] | |||
MMP-1 gene expression has also been shown to have implications with cancer treatment. MMP-1 can be used as a candidate marker that may be useful for identification of breast lesions that can develop into cancer [5]. | MMP-1 gene expression has also been shown to have implications with cancer treatment. MMP-1 can be used as a candidate marker that may be useful for identification of breast lesions that can develop into cancer [5]. | ||
== References == | == References == | ||
