Sandbox Reserved 452: Difference between revisions

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== Mechanism ==

Most of the biological functions that c-myc performs involves herterodimerization with Max. C-Myc primary function is activating the transcription of genes involved in cell proliferation, growth, and metabolism by binding to the DNA sequence CAGTG, also known as the Enhancer box, when it has dimerized with Max. When c-Myc/Max form a herterodimer transcription can be repressed because these dimers interact specifically with transcriptional activators which main function includes recognizing the promotor for specific genes. If the promotor is not recognized then transcription cannot occur. When transcription does not occur the genes for inhibiting the cell cycle and specific proteins for cell adhesion are repressed.

Most of the biological functions that c-myc performs involves herterodimerization with Max. C-Myc primary function is activating the transcription of genes involved in cell proliferation, growth, and metabolism by binding to the DNA sequence CAGTG, also known as the Enhancer box, when it has dimerized with Max. Many studies have shown that without dimerizing to Max, c-Myc would not be able to bind to DNA, which makes thier interaction important to cellular function<ref>PMID:1501888</ref>. When c-Myc/Max form a herterodimer transcription can be repressed because these dimers interact specifically with transcriptional activators which main function includes recognizing the promotor for specific genes. If the promotor is not recognized then transcription cannot occur. When transcription does not occur the genes for inhibiting the cell cycle and specific proteins for cell adhesion are repressed.

Sandbox Reserved 452: Difference between revisions

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Revision as of 14:08, 1 May 2012 view source Megan R. Askew (talk \| contribs) 91 edits No edit summary ← Older edit		Revision as of 15:01, 1 May 2012 view source Megan R. Askew (talk \| contribs) 91 edits No edit summary Newer edit →
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	== Mechanism ==		== Mechanism ==
	Most of the biological functions that c-myc performs involves herterodimerization with Max. C-Myc primary function is activating the transcription of genes involved in cell proliferation, growth, and metabolism by binding to the DNA sequence CAGTG, also known as the Enhancer box, when it has dimerized with Max. When c-Myc/Max form a herterodimer transcription can be repressed because these dimers interact specifically with transcriptional activators which main function includes recognizing the promotor for specific genes. If the promotor is not recognized then transcription cannot occur. When transcription does not occur the genes for inhibiting the cell cycle and specific proteins for cell adhesion are repressed.		Most of the biological functions that c-myc performs involves herterodimerization with Max. C-Myc primary function is activating the transcription of genes involved in cell proliferation, growth, and metabolism by binding to the DNA sequence CAGTG, also known as the Enhancer box, when it has dimerized with Max. Many studies have shown that without dimerizing to Max, c-Myc would not be able to bind to DNA, which makes thier interaction important to cellular function<ref>PMID:1501888</ref>. When c-Myc/Max form a herterodimer transcription can be repressed because these dimers interact specifically with transcriptional activators which main function includes recognizing the promotor for specific genes. If the promotor is not recognized then transcription cannot occur. When transcription does not occur the genes for inhibiting the cell cycle and specific proteins for cell adhesion are repressed.