Sandbox Reserved 470: Difference between revisions
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'''[[Glyceraldehyde-3-phosphate Dehydrogenase]]''' | '''[[Glyceraldehyde-3-phosphate Dehydrogenase]]''' | ||
<Structure load='3gpd' size='500' frame='true' align='right' caption='Glyceraldehyde-3-phosphate Dehydrogenase' scene='Insert optional scene name here' /> | <Structure load='3gpd' size='500' frame='true' align='right' caption='Glyceraldehyde-3-phosphate Dehydrogenase' scene='Insert optional scene name here' /><scene name='Sandbox_Reserved_470/Active_site_gapdh/1'>active site</scene> | ||
(abbreviated as GAPDH or the less common G3PDH) (EC 1.2.1.12) ~37kDa catalyzes the sixth step of glycolysis, a reversible cytosolic process in eukaryotes which involves the breakdown of glucose for energy and carbon molecules. Along with its role in glycolysis and gluconeogenesis, recent research has determined that GAPDH is actually a multifunctional protein, as it has numerous defined, non-metabolic functions involved in multiple subcellular processes including transcription activation, ER to Golgi transportation, transcriptional control of histone gene expression, nuclear membrane fusion, neuronal initiation of apoptosis, recognizing fraudulently incorporated nucleotides in DNA, and maintaining telomere structures. Research also shoes that it possibly has a direct involvement in cellular phenotype of human neurodegenerative disorders, especially those characterized by expansion of CAG repeats. | (abbreviated as GAPDH or the less common G3PDH) (EC 1.2.1.12) ~37kDa catalyzes the sixth step of glycolysis, a reversible cytosolic process in eukaryotes which involves the breakdown of glucose for energy and carbon molecules. Along with its role in glycolysis and gluconeogenesis, recent research has determined that GAPDH is actually a multifunctional protein, as it has numerous defined, non-metabolic functions involved in multiple subcellular processes including transcription activation, ER to Golgi transportation, transcriptional control of histone gene expression, nuclear membrane fusion, neuronal initiation of apoptosis, recognizing fraudulently incorporated nucleotides in DNA, and maintaining telomere structures. Research also shoes that it possibly has a direct involvement in cellular phenotype of human neurodegenerative disorders, especially those characterized by expansion of CAG repeats. | ||
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