Sandbox Reserved 470: Difference between revisions

<Structure load='3gpd' size='400' frame='true' align='right' caption='Glyceraldehyde-3-phosphate Dehydrogenase' scene='Insert optional scene name here' />(abbreviated as GAPDH or the less common G3PDH) (EC 1.2.1.12) ~37kDa  is a well-known [[enzyme]] which catalyzes the sixth step of [[glycolysis]], a reversible cytosolic process in [[eukaryotes]] which involves the breakdown of glucose for energy and carbon molecules.  Along with its role in glycolysis and [[gluconeogenesis]], recent research has determined that GAPDH is actually a multifunctional protein, as it has numerous defined, non-metabolic functions involved in multiple subcellular processes including [[transcription]] activation, ER  to Golgi transportation, transcriptional control of histone [[gene expression]], nuclear membrane fusion, neuronal initiation of [[apoptosis]], recognizing fraudulently incorporated nucleotides in DNA, and maintaining [[telomere]] structures.  Research also shows that it possibly has a direct involvement in cellular phenotype of human [[neurodegenerative]] disorders, especially those characterized by expansion of [[CAG repeats]].