1onq: Difference between revisions

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==Overview==

CD1 antigens bind a variety of self and foreign lipid and glycolipid, antigens for presentation to CD1-restricted T cell receptors (TCRs). Here, we report the crystal structure of human CD1a in complex with a sulfatide, self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped, conformation, with the sphingosine chain completely buried in the A', pocket and the fatty acid chain emerging from the interface of the A', pocket into the more exposed F' pocket. The headgroup is anchored in the, A'-F' junction and protrudes into the F' pocket for TCR recognition., Because the A' pocket is narrow with a fixed terminus, it can act as a, molecular 'ruler' to select alkyl chains of a particular length.

CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped conformation, with the sphingosine chain completely buried in the A' pocket and the fatty acid chain emerging from the interface of the A' pocket into the more exposed F' pocket. The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Elsliger, M.A.]]

[[Category: Elsliger, M A.]]

[[Category: Teyton, L.]]

[[Category: Wilson, I.A.]]

[[Category: Wilson, I A.]]

[[Category: Zajonc, D.M.]]

[[Category: Zajonc, D M.]]

[[Category: FUC]]

[[Category: NAG]]

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[[Category: protein-glycolipid complex]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:19:43 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-CD1 antigens bind a variety of self and foreign lipid and glycolipid, antigens for presentation to CD1-restricted T cell receptors (TCRs). Here, we report the crystal structure of human CD1a in complex with a sulfatide, self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped, conformation, with the sphingosine chain completely buried in the A', pocket and the fatty acid chain emerging from the interface of the A', pocket into the more exposed F' pocket. The headgroup is anchored in the, A'-F' junction and protrudes into the F' pocket for TCR recognition., Because the A' pocket is narrow with a fixed terminus, it can act as a, molecular 'ruler' to select alkyl chains of a particular length.
+CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. The lipid adopts an S-shaped conformation, with the sphingosine chain completely buried in the A' pocket and the fatty acid chain emerging from the interface of the A' pocket into the more exposed F' pocket. The headgroup is anchored in the A'-F' junction and protrudes into the F' pocket for TCR recognition. Because the A' pocket is narrow with a fixed terminus, it can act as a molecular 'ruler' to select alkyl chains of a particular length.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Elsliger, M.A.]]
+[[Category: Elsliger, M A.]]
 [[Category: Teyton, L.]]
-[[Category: Wilson, I.A.]]
+[[Category: Wilson, I A.]]
-[[Category: Zajonc, D.M.]]
+[[Category: Zajonc, D M.]]
 [[Category: FUC]]
 [[Category: NAG]]
@@ Line 26: / Line 26: @@
 [[Category: protein-glycolipid complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:34:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:19:43 2008''