User:Marvin O'Neal/OspC: Difference between revisions
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are more highly variable than those present in the loops, | are more highly variable than those present in the loops, | ||
<scene name='Studio:G4SecL04/L4/1' >L4</scene> (residues 115-119)and | <scene name='Studio:G4SecL04/L4/1' >L4</scene> (residues 115-119)and | ||
<scene name='Studio:G4SecL04/L6/1'>L6</scene> (residues 161-169). Consequently, the surface potential of red region that projects away from the membrane is negatively charged and mainly involved in the protein-protein or protein-ligand interactions | <scene name='Studio:G4SecL04/L6/1'>L6</scene> (residues 161-169). Consequently, the surface potential of red region that projects away from the membrane is negatively charged and mainly involved in the protein-protein or protein-ligand interactions <ref name= variable>PMID: 11139584 </ref>. Only four types of oMGs (A, B, I and K), whose surface potential in red region is highly negative relative to non-invasive one plays a major role in pathogenesis of human Lyme disease | ||
<ref name="human lyme disease">Kumaran D, Eswaramoorthy S, Luft B, Koide S, Dunn J, Lawson C, and Swaminathan S. 2001. Crystal Structure of Outer Surface Protein C (OspC) from the Lyme Disease Spirochete, ''Borrelia burgdorferi''. The EMBO Journal 20(5): 971-978. [http://dx.crossref.org/10.1093%2Femboj%2F20.5.971 DOI: 10.1093/emboj/20.5.971]</ref>. | <ref name="human lyme disease">Kumaran D, Eswaramoorthy S, Luft B, Koide S, Dunn J, Lawson C, and Swaminathan S. 2001. Crystal Structure of Outer Surface Protein C (OspC) from the Lyme Disease Spirochete, ''Borrelia burgdorferi''. The EMBO Journal 20(5): 971-978. [http://dx.crossref.org/10.1093%2Femboj%2F20.5.971 DOI: 10.1093/emboj/20.5.971]</ref>. | ||
The residue, | The residue, | ||
