Sandbox Reserved 490: Difference between revisions
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Estrogen receptors have two important structural components: the DNA-binding domain and the ligand-binding domain. | Estrogen receptors have two important structural components: the DNA-binding domain and the ligand-binding domain. | ||
''DNA-Binding domain'' | ''DNA-Binding domain[http://www.rcsb.org/pdb/explore/explore.do?structureId=1hcq]'' | ||
<Structure load='1hcq' size='500' frame='true' align='right' caption='ER DBD' scene='' /> | <Structure load='1hcq' size='500' frame='true' align='right' caption='ER DBD' scene='' /> | ||
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''Ligand-binding domain'' | ''Ligand-binding domain[http://www.rcsb.org/pdb/explore/jmol.do?structureId=1A52&bionumber=1]'' | ||
<Structure load='1a52' size='500' frame='true' align='right' caption='ER LBD' scene='Insert optional scene name here' /> | <Structure load='1a52' size='500' frame='true' align='right' caption='ER LBD' scene='Insert optional scene name here' /> | ||
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The ligand used to determine this structure was estradiol, which is the physiologically appropriate ligand. Estradiol, or estrogen, has the following structure: | The ligand used to determine this structure was estradiol, which is the physiologically appropriate ligand. Estradiol, or estrogen, has the following structure: | ||
[[Image:content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.17b-estradiol.1.jpg]] | [[Image:http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.17b-estradiol.1.jpg]] | ||
==Mechanism of Action== | |||
